sing impulse oscillometry, multiple-breath nitrogen washout and exhaled nitric oxide together to assess asthma inflammatio

Phase 4

Completed

• Conditions: Asthma; Respiratory - Asthma

• Registration Number: ACTRN12619000287134
• Lead Sponsor: niversity of Otago

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-02-26
• Study Completion: 2019-11-15
• Last Update Posted: 10 February 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Physician-diagnosed asthma requiring a minimum of treatment with regular inhaled corticosteroid.

Exclusion Criteria

Diagnosis of COPD, bronchiectasis, lung cancer.
Other co-morbidity likely to affect study participation.
Current smoker (any cigarette smoking within past two months).
Previous ICU admission for acute asthma.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in exhaled nitric oxide measured by exhaled nitric oxide analyser[Change from baseline to 30 min post dosing.]

Secondary Outcome Measures

Name	Time	Method
Change in area of reactance measured by impulse oscillometry.[Change from baseline to 30 min post dosing.];Change in lung clearance index measured by multiple breath nitrogen washout.[Change from baseline to 30 min post dosing.];Change in Scond (index of ventilation heterogeneity in the conducting airways) measured by multiple breath nitrogen washout.[Change from baseline to 30 min post dosing.];Change in Sacin (index of ventilation heterogeneity in the acinar airways) measured by multiple breath nitrogen washout.[Change from baseline to 30 min post dosing.];Change in forced vital capacity measured by spirometry.[Change from baseline to 30 min post dosing.];Change in R5-R20 measured by impulse oscillometry.[Change from baseline to 30 min post dosing.]