Development of a New Method for Steady-State Measurement of NO Lung Diffusing Capacity in Healthy Subjects
Phase 1
- Conditions
- Pulmonary Diffusing Capacity
- Registration Number
- NCT00315965
- Lead Sponsor
- University Hospital Tuebingen
- Brief Summary
Using a rapidly responding nitric oxide analyzer in a new developed modular lung-function-setup we are going to measure steady-state NO diffusing capacity in 107 healthy subjects (age 6-45 years). The results will be compared to those measured by using carbon monoxide single-breath estimates. We like to show that the new method is sufficient to measure exactly lung diffusion capacity in this collective.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 107
Inclusion Criteria
- Healthy volunteers
- Lung function testing possible
- Written consent
Exclusion Criteria
- Pulmonary, neuromuscular, cardiovascular, endocrinological illness
- Pregnancy
- Abuse of nicotine, alcohol, drugs during the last two years
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method TLCOsb TLNOss
- Secondary Outcome Measures
Name Time Method Breathing frequency tidal volume functional residual capacity airway resistance lung clearance index forced expiratory volume in one second vital capacity total lung capacity
Trial Locations
- Locations (1)
University children´s hospital
🇩🇪Tuebingen, Germany