Evaluation of Automatic Oxygen Flow Titration During Walking in Patients With COPD

Not Applicable

Completed

• Conditions: COPD; Exercise; Endurance Shuttle Walking Test (Exercise at 85% of Maximal Shuttle Walking Test)
• Interventions: Drug: Compressed air; Drug: Oxygen constant flow; Device: Automated oxygen titration

• Registration Number: NCT02150434
• Lead Sponsor: Laval University

Brief Summary

The aim of the current study was to evaluate a new system (FreeO2) that automatically titrates oxygen flow to maintain stable SpO2, in patients with moderate or severe chronic obstructive pulmonary disease during exercise. The investigators hypothesized that continuous automatic adjustment of the oxygen flows during exercise would better maintain patients within the oxygenation target, reduce episodes of desaturation and hyperoxia and would improve walking exercise tolerance in comparison with fixed levels of low-flow oxygen and with compressed air breathing.

Detailed Description

Not available

Study Timeline

• Study Start: 2009-11
• Primary Completion: 2012-05
• Study Completion: 2013-06
• Status Verified: 2014-05
• Study First Submitted: 2014-05-26
• Study First Submitted QC: 2014-05-28
• Last Update Submitted: 2014-05-28
• Study First Posted: 2014-05-29
• Last Update Posted: 2014-05-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 16

Inclusion Criteria

• Patients older than 40 years
• Moderate to severe COPD according to the Global Initiative for Chronic Obstructive Lung Disease guidelines
• Who did not require long-term oxygen therapy were included in the study.
• Patients were also selected on the basis of known (end-exercise SpO2 < 90% on a previous exercise test) or suspected (SpO2 < 95% at rest) desaturation during exercise

Exclusion Criteria

• Episode of exacerbation or hospitalisation within last four weeks
• Current medical condition that could influence exercise tolerance

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Compressed Air	Compressed air	compressed air delivered at a fixed flow of 2 L/min
Oxygen constant flow	Oxygen constant flow	oxygen delivered at a fixed flow of 2L/min
Automated oxygen titration	Automated oxygen titration	oxygen at a variable flows delivered by the FreeO2

Primary Outcome Measures

Name	Time	Method
Time within predefined SpO2 target	during exercise (Endurance shuttle walking test)	The primary outcome of the study was the percentage of exercise time during which patients were kept within the SpO2 target of 92 to 96%

Secondary Outcome Measures

Name	Time	Method
Exercise tolerance	duration of ESWT	Endurance shuttle walking test time and distance

Trial Locations

Locations (1)

Centre de recherche de l'IUCPQ; 🇨🇦 Québec, Quebec, Canada