Stimulation Therapy in Military Veterans

Completed

• Conditions: post-traumatic stress disorder; anxiety disorder; intermittent explosive disorder; impulsive aggression; 10002861

• Registration Number: NL-OMON46862
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2020-10-10
• Results First Posted: 2021-07-26
• Last Update Posted: 11 June 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 96

Inclusion Criteria

- Dutch military personnel
- Age 18 - 60 years
- Presence of problems with aggression regulation according to criteria as described in (Coccaro, 2012) or any anxiety disorder according to DSM-IV criteria except for obsessive-compulsive disorder (OCD)
- Receive treatment for above-mentioned symptoms
- Provide written informed consent

Exclusion Criteria

- Predominant major depressive disorder (MDD)
- Alcohol or drug dependence
- Severe psychiatric or neurological disorders, e.g., Parkinson*s disease.
- Serious head trauma or brain surgery (N.B. TBI without brain damage or skull damage is not a reason for exclusion)
- Large or ferromagnetic metal parts in the head (except for a dental wire)
- Implanted cardiac pacemaker or neurostimulator
- Pregnancy
- Concurrent or recent (within previous month) participation in a neuromodulation / neurostimulation (e.g., tDCS, TMS) experiment.
- Skin damage or diseases at intended electrode sites (tDCS)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameter is the pre-to post-intervention change in inhibitory<br /><br>control on the training task (stop-signal task).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Second, we aim to test the pre-to post-intervention changes in symptoms related<br /><br>to anxiety and aggression, threat-related (emotional Go/No-Go task) and<br /><br>implicit inhibitory control (implicit association task). Additionally we look<br /><br>at post-intervention attentional threat avoidance (dot-probe task). Finally, we<br /><br>assess symptom reduction at 3 and 12 months follow-up.</p><br>