Prevalence and Clinical Characteristics of Patients With Jackhammer Esophagus and Symptoms of Gastroesophageal Reflux Disease

Completed

• Conditions: Esophageal Motility Disorders

• Registration Number: NCT03347903
• Lead Sponsor: Medical University of Vienna

Brief Summary

Gastroesophageal reflux disease (GERD) is involved in the development of esophageal motility disorders like Jackhammer esophagus (JE), a novel hypercontractile condition that was associated with progression to achalasia and limited outcomes following surgical anti-reflux therapy.

This trial was designed to assess the prevalence and characteristics of JE in patients with typical symptoms of GERD and responsiveness to PPI therapy.

Detailed Description

Jackhammer esophagus is a novel hypercontractile esophageal disorder. The investigators assess the prevalence and clinical characteristics of patients diagnosed with this disorder out of a collective of patients that are referred with symptoms of gastroesphageal reflux disease and respond to PPI. This is an observational trial.

Study Timeline

• Study Start: 2014-01-01
• Primary Completion: 2017-05-30
• Study Completion: 2017-05-30
• Status Verified: 2017-11
• Study First Submitted: 2017-11-15
• Study First Submitted QC: 2017-11-15
• Last Update Submitted: 2017-11-18
• Study First Posted: 2017-11-20
• Last Update Posted: 2017-11-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 37

Inclusion Criteria

• Patients with symptoms of gastroesophageal reflux disease and diagnosis of Jackhammer esophagus

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Exclusion Criteria

• patients not willing to participate data or undergo screening for gastroesophageal reflux disease

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Prevalence of Jackhammer esophagus in patients referred with symptoms of gastroesophageal reflux disease	January 2014- May 2017	All patients that are referred to our center with symptoms of gastroesophageal reflux disease routinely undergo high-resolution manometry. We assess how many patients are diagnosed with Jackhammer esophagus

Secondary Outcome Measures

Name	Time	Method
Symptom perception	January 2014- May 2017	We assess which symptoms are perceived by the patients diagnosed with Jackhammer esophagus. All data are observed during an interview at the high-resolution manometry
Prevalence of gastroesophageal reflux disease in patients with Jackhammer esophagus	Januar 2014- May 2017	All patients that are referred to our center are evaluated for gastroesophageal reflux disease. We assess the prevalence of gastroesophageal reflux disease in patients with Jackhammer esophagus diagnosed by ambulatory pH monitoring.