Effect of Yoga in male infertility

Recruiting

• Conditions: Male infertility, unspecified,

• Registration Number: CTRI/2021/02/031131
• Lead Sponsor: DST

Brief Summary

The stressors in complexmodern lifestyle seem to be accelerating and have been proposed to be thecontributors to various “lifestyle related†chronic diseases such asdepression, heart diseases and diabetes. These have been implicated as one ofthe causal factors in the etiology of various reproductive disorders likeinfertility, early pregnancy loss, implantation failures in IVF cycles andcongenital malformations due to alarming effects on the health of the futureprogeny. The paternal contribution has important implications in fertilizationand for understanding early developmental process and their effect on outcomeof the future progeny. The effects are adverse due to decrease in quality oflife and poor response to pharmacologic treatment. The impact of antioxidant onnuclear DNA damage is still controversial. Efforts are underway to findnon-pharmacologic therapies to relieve stress and anxiety, and adoption of yogaas an integral part of our lifestyle is a promising beneficial treatmentmodality. Yoga, the ancient Indian discipline, is aimed at achieving union andharmony between our mind and body, and brings balance to all aspects of one’sbeing. It is a highly advanced technique for attaining perfect alignment ofbody and prepare it for meditation.

Since we havealready shown in our previously published studies that ROS causes bothmitochondrial and nuclear DNA damage hence we propose (in this study) to assessboth oxidative stress and oxidative DNA damage in semen (1, 2, 3). Ongoingstudies from our laboratory have also shown the beneficial effect of the briefYBLI for 21 days in modifying the gene expression in male partners with coupleswith recurrent implantation failure as well as recurrent pregnancy loss (4).The effect of quitting smoking, alcohol intake, deep breathing (Pranayama)along with modifying factors of lifestyle interventions like “Yoga†and“Meditation†can, therefore, be evaluated by the measurement of oxidativestress, DNA damage, telomere dynamics and gene expression. In the presentproposal, we plan to study the effect of lifestyle modifying factors andpotential interventions on the sperm integrity and expression of mRNA andmiRNAs by enrolling patients for yoga and meditation based lifestyleintervention (YBLI).

Detailed Description

Not available

Study Timeline

• Study Start: 2021-01-03
• Last Update Posted: 2021-09-12

Recruitment & Eligibility

• Status: Open to Recruitment
• Sex: Male
• Target Recruitment: 150

Inclusion Criteria

a.Group I- idiopathic primary infertility b.Group II- Male partners of couples with >2 pregnancy losses c.Group III- Male partners of couples with >2 implantation failures in IVF cycles d.Age <45 years e.Willing to attend full course of intervention f.Conversant in Hindi and/or English.

Exclusion Criteria

• a.Refusal to participate in study b.Recent history of any febrile illness, inflammatory disorders c.History of drug intake in the last 3 months d.Patients on any co-morbid medical conditions e.
• Patients with any abnormal chromosomal complement.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
spermatozoal transcripts and miRNA	pre intervention day 0 and post- day 10, day 30 and day 90

Secondary Outcome Measures

Name	Time	Method
Sperm parameters	pre intervention day 0 and post- day 10, day 30 and day 90

Trial Locations

Locations (1)

All India Institute of Medical Sciences, New Delhi; 🇮🇳 South, DELHI, India

All India Institute of Medical Sciences, New Delhi

🇮🇳South, DELHI, India

Prof Rima Dada

Principal investigator

011-26593517

rima_dada@rediffmail.com