Angiogenic Biomarkers in Juvenile Idiopathic Arthritis
- Conditions
- Juvenile Idiopathic Arthritis (JIA)
- Interventions
- Biological: Blood sampleBiological: Joint puncture
- Registration Number
- NCT05534347
- Lead Sponsor
- Assistance Publique - HĂ´pitaux de Paris
- Brief Summary
The aim of the study is to determine whether serum inflammatory angiogenic markers (eg, semaphorins, CCN1) predict severity of juvenile idiopathic arthritis defined by structural progression and/or therapeutic escalation.
- Detailed Description
Juvenile idiopathic arthritis (JIA) is a heterogeneous group of chronic inflammatory rheumatic diseases beginning before the age of 16. The most common pediatric rheumatologic disease. JIA is the most common pediatric rheumatologic disease. Apart from clinical features and the biological inflammatory syndrome, no predictive parameter for the severity of JIA, especially polyarticular JIA, has been identified. The team has been interested in the prognosis of RA for many years. Thus, the investigators have conducted various studies in search of biological parameters associated with the joint prognosis of RA patients, which allowed the investigator to discover the interest of angiogenic and inflammatory biomarkers such as semaphorins and CCN1 protein. This has been demonstrated in vitro but also in vivo from sera of RA patients. These markers are associated with activity and structural damage in RA.
The project aims to study the interest of these same angiogenic biomarkers in the serum of JIA patients in order to establish whether, as in RA, they are also associated with disease severity.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 300
- Greater than or equal to 16 years-old
- Diagnosis of Juvenile Idiopathic Arthritis with specialized follow up in Rheumatology at Cochin Hospital
- No-opposition to the research
- Patient with health insurance
- Mastery of the French language
- Patient under curatorship or guardianship
- Patient receiving french state medical aid
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Juvenile Idiopathic Arthritis Blood sample Patients seen in a specialized rheumatology consultation for the management of juvenile idiopathic arthritis in an adult service, after information and collection of their non-opposition. Juvenile Idiopathic Arthritis Joint puncture Patients seen in a specialized rheumatology consultation for the management of juvenile idiopathic arthritis in an adult service, after information and collection of their non-opposition.
- Primary Outcome Measures
Name Time Method Dosage of angiogenic markers 5 years Dosage of angiogenic markers by ELISA method in synovial fluid if available. Determine if angiogenic and inflammatory biomarkers are predictive of a more severe disease as reflected by structural joint damage and treatments received.
Activity measured with questionnaires, and treatments received. Structural damage determined by x-rays during follow up.Dosage of inflammatory markers by ELISA method 5 years Dosage of inflammatory markers by ELISA method in synovial fluid if available. Determine if angiogenic and inflammatory biomarkers are predictive of a more severe disease as reflected by structural joint damage and treatments received.
Activity measured with questionnaires, and treatments received. Structural damage determined by x-rays during follow up.
- Secondary Outcome Measures
Name Time Method Collection of treatments received 5 years Severity of JIA
Inflammatory biomarkers At inclusion Determine if sera inflammatory biomarkers are associated with clinical subtypes of JIA.
Questionnaires 5 years Severity of JIA
Angiogenic biomarkers At inclusion Determine if sera angiogenic biomarkers are associated with clinical subtypes of JIA.
Structural damage determined by x-rays 5 years Structural damage determined by x-rays during follow up.
Trial Locations
- Locations (1)
Rheumatology Department, Cochin Hospital
🇫🇷Paris, IDF, France