The Effect of a Complete Course of Antenatal Steroids on Mortality and Morbidity of Preterm Infants
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Morbidity;Newborn
- Sponsor
- Hospital General Universitario Gregorio Marañon
- Enrollment
- 710
- Locations
- 1
- Primary Endpoint
- Mortality
- Last Updated
- 6 years ago
Overview
Brief Summary
The aim is to evaluate the impact of a complete course of antenatal steroids treatment on mortality and main morbidities in a current population of preterm infants.
Detailed Description
All infants admitted in the Neonatal Department born with less than 32 weeks of gestational age are included. Data are prospectively recorded. Perinatal variables (Gestational age, materna condition at admission, antenatal steroids treatment, gender and results of histological analysis of the placenta) are recorded as well as respiratory status during hospitalization and morbidities at discharge. Results of neurodevelopment test performed at 24 months of corrected age are also included.
Investigators
Manuel Sanchez Luna
Medical Doctor. Pediatric Profesor
Hospital General Universitario Gregorio Marañon
Eligibility Criteria
Inclusion Criteria
- •All infants admitted in the NICU (with less than 6 hours after birth) born with less than 32+0 weeks of gestational age (GA).
Exclusion Criteria
- •Congenital malformations.
- •premature infants in whom active resuscitation measures are not established.
Outcomes
Primary Outcomes
Mortality
Time Frame: at hospital discharge, an average of 2-4 months.
Secondary Outcomes
- Number of participants with Bronchopulmonary dysplasia (BPD) diagnosis.(36 weeks postmenstrual age)
- Number of participants requiring Surfactant administration(in the first 3 days after birth)
- Number of participants that requires Mechanical ventilation.(during hospitalization, and average of 2-4 months)
- Number of participants with Neurodevelopment disability(performed at 24 months)