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临床试验/NCT07345832
NCT07345832
尚未招募
不适用

Digital Pathway to Healthy Aging: Sarcopenia-Frailty Integrated Training

The University of Hong Kong1 个研究点 分布在 1 个国家目标入组 200 人开始时间: 2026年2月28日最近更新:

概览

阶段
不适用
状态
尚未招募
入组人数
200
试验地点
1
主要终点
Appendicular skeletal muscle mass index (ASMI)

概览

简要总结

Sarcopenia and frailty prevention and management are highly prioritized goals in the Healthy Aging agenda. The study aims to evaluate the effects and implementation of the digital critical pathway to improve sarcopenia and frailty, reduce fall risk, and increase health-related quality of life among community-dwelling older adults with risk of, or diagnosed with, sarcopenia and frailty

详细描述

Population ageing is accelerating globally and regionally, widening the gap between life expectancy and healthy life expectancy, mainly due to late-life declines in physical function and mobility (Guo et al., 2022). Sarcopenia and frailty are major age-associated public health issues that contribute to a decline in functional ability, increased fall risks, and mortality (Lee et al., 2022; Petermann-Rocha et al., 2021). Nutrition and physical activity integrated interventions are recommended as primary treatment for sarcopenia and frailty (Park & Lee, 2023). However, current interventions are often generic, resulting in non-precise, non-personalized interventions, usually failing to accommodate individual differences in baseline strength and mobility, nutrition status, comorbidities, preferences, and home environments (Tighe et al., 2020). Consequently, interventions are complex to personalise, adjustments are delayed, and adherence is suboptimal, undermining real-world effectiveness. Future community-based health agendas should prioritize long-term care that removes access barriers (such as mobility and transportation) and transitions from generic care to precision personalization.

The World Health Organisation's Decade of Healthy Ageing and the Integrated Care for Older People (ICOPE) framework provide a practice anchor to maintain intrinsic capacity through person-centred assessment, individualised goal-setting, and continuous follow-up. Within this paradigm, sarcopenia and frailty management apply ICOPE via protocol-driven critical pathways (Sum et al., 2022)-structured decision support that links risk assessment to tailored prescriptions and follow-up-can standardise quality while enabling precise personalisation across diverse home settings.

Digital health interventions have expanded their capabilities to include remote exercise prescription, microlearning, reminders, and tele-coaching, with evidence of benefits for physical activity, fitness, body composition, and patient-reported outcomes (De Santis et al., 2023). Utilising a user-friendly digital tool to streamline functional assessments and develop personalised health plans is a promising approach.

A digital platform-enabled intervention, grounded in the WHO ICOPE framework and a protocol-driven critical pathway, is proposed to identify care needs among community-dwelling older adults. This tool will allow healthcare providers to accurately assess individual needs and tailor interventions in exercise and nutrition, ensuring a focused, effective approach to combating sarcopenia and frailty in older adults.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Prevention
盲法
Single (Outcomes Assessor)

盲法说明

Outcome assessors will be blinded to the intervention assignment results.

入排标准

年龄范围
60 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • aged 60 or above
  • Pseudo-Sarcopenia/Sarcopenia: SARC-CaIF ≥ 11, AND (Grip Strength on dominant hand (male \<28 kg, female \<18 kg), OR Chair Stand Test (5 times) ≥ 12 seconds, OR Short Physical Performance Battery Score ≤ 9; OR relative appendicular skeletal mass/ height (Men: \<7 kg/m2; women: \<5.7 kg/m2) ); AND/OR Prefrail/ frail based on the Edmonton Frail Scale Score ≥
  • consent to participate

排除标准

  • having conditions contradictory to physical activity
  • engaging in other ongoing physical activity and nutrition programs

研究组 & 干预措施

Digital Pathway to Healthy Aging: Sarcopenia-Frailty Integrated Training program

Experimental

This digital program will address sarcopenia and frailty with a 12-week integrated intervention based on integrated exercise, nutrition, and fall-prevention.

干预措施: Digital Pathway to Healthy Aging: Sarcopenia-Frailty Integrated Training program (D-Path-HA: S-FIT) (Behavioral)

Waitlist Control

Active Comparator

The control group will receive general education on nutrition and physical activity guidelines for older adults, and the same pathway intervention will be applied to the control group after all data collection

干预措施: Waitlist Control (Behavioral)

结局指标

主要结局

Appendicular skeletal muscle mass index (ASMI)

时间窗: Baseline (T0), 3 months (T1), and 6 months (T2)

Appendicular skeletal muscle mass index (ASMI) measured by Bioelectrical impedance analysis (BIA)

Handgrip Strength

时间窗: Baseline (T0), 3 months (T1), and 6 months (T2)

Handgrip strength will be measured by a hydraulic hand dynamometer from dominant hand, taking the highest value among 3 measurements. Low muscle strength is defined if male \<28kg, and femal \<18kg.

Short Physical Performance Battery (SPPB)

时间窗: baseline (T0), 3 months (T1), and 3 months (T2)

Physical function will be measured by the Short Physical Performance Battery (SPPB), which combines balance test, gait velocity and chair stand. SPPB score ranges from 0-12, higher score better physical performance. Low physical function is defined by SPPB score ≤9.

次要结局

  • Sarcopenia and calf circumference scale (SARC-CalF)(Baseline (T0), 3 months (T1), and 6 months (T2))
  • 11-item Edmonton Frail Scale(Baseline (T0), 3 months (T1), and 6 months (T2))
  • Timed Up and Go (TUG) test(Baseline (T0), 3 months (T1), and 6 months (T2))
  • The Mini Nutritional Assessment (MNA)(Baseline (T0), 3 months (T1), and 6 months (T2))
  • International Physical Activity Questionnaire (IPAQ-Short)(Baseline (T0), 3 months (T1), and 6 months (T2))
  • Sleep duration(Baseline (T0), 3 months (T1), and 6 months (T2))
  • The EuroQoL-5D-5L instruments(Baseline (T0), 3 months (T1), and 6 months (T2))

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Prof. Yu, Doris Sau Fung

Professor

The University of Hong Kong

研究点 (1)

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