FinnDiane LifeOne Study - Impact of Ageing on People With Type 1 Diabetes
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 入组人数
- 400
- 试验地点
- 1
- 主要终点
- Healthy ageing in people with type 1 diabetes mellitus
研究概览
简要总结
Healthy aging refers to functional ability that enables well-being in older individuals. The focus thus shifts from chronological age to functional capacity and the individual's own experience of well-being. Type 1 diabetes is a chronic condition characterized by elevated blood glucose levels, which increases the risk of cardiovascular diseases and premature death. However, the life expectancy of individuals with type 1 diabetes has significantly improved due to advances in diabetes care.
There is limited research on aging with type 1 diabetes, and this study is at the forefront of addressing this gap by examining aging-and especially healthy aging-in type 1 diabetes from multiple perspectives. The goals are to investigate how individuals with type 1 diabetes age and what their functional capacity is compared to individuals without insulin-treated diabetes. The other aim is to identify factors in midlife that predict healthy aging in people with type 1 diabetes.
详细描述
Ageing with type 1 diabetes is an emerging challenge due to improved life-expectancy of people with type 1 diabetes. While those who survive to an older age are considered survivors, the many years with type 1 diabetes and the chronic dysglycaemia inevitably also has negative health impacts on people living with this chronic disease. With scarce research in this area, ageing in type 1 diabetes has been identified as a research gap.
With this study, the aim is to assess the impact of ageing in people with type 1 diabetes via thorough characterization of older adults with type 1 diabetes, in comparison to matched controls. This will be accomplished through a comprehensive assessment of the participants' metabolic profile, body composition, vascular health, autonomic function, and a geriatric assessment focusing on the functional ability of the participants. In addition, this study will assess what type of challenges older adults with type 1 diabetes face regarding self-management, diabetes care, and daily life.
This study is a sub-study of the national Finnish Diabetic Nephropathy Study, initiated in 1997 and including adults with type 1 diabetes. Individuals over 65 living in the Helsinki capital area will now be invited for a regular FinnDiane study visit, as well as an additional visit for a geriatric assessment. The aim is to study 300 FinnDiane study participants and recruit a minimum of 100 matched controls. This cohort will be prospectively followed with a revisit after three to five years.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Participants of the Finnish Diabetic Nephropathy Study
- •Type 1 diabetes
- •With age above 65 years
- •Informed consent provided
排除标准
- •Age below 65 years
结局指标
主要结局
Healthy ageing in people with type 1 diabetes mellitus
时间窗: From initial enrollment in the FinnDiane Study until the LifeOne follow-up visit after three to five years.
Key Characteristics and Clinical Implications of healthy aging in individuals with type 1 diabetes mellitus
次要结局
- Physical capacity(From initial enrollment in the FinnDiane Study until the LifeOne follow-up visit after three to five years.)
- Cognitive function(From initial enrollment in the FinnDiane Study until the LifeOne follow-up visit after three to five years.)
- Psychological well-being(From initial enrollment in the FinnDiane Study until the LifeOne follow-up visit after three to five years.)
- Vitality(From initial enrollment in the FinnDiane Study until the LifeOne follow-up visit after three to five years.)
- Sensory function(From initial enrollment in the FinnDiane Study until the LifeOne follow-up visit after three to five years.)
研究者
Lena M. Thorn
Associate professor, Head physician, Helsinki University Hospital
Helsinki University Central Hospital