Central Venous-arterial Carbon Dioxide Pressure Difference in Correlation to Dynamic Changes of Serum Lactate as an Indicator of Tissue Perfusion in Polytruama Patients
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Multiple Trauma
- Sponsor
- Assiut University
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- the difference between partial pressure of oxygen in arterial and venous blood
- Last Updated
- 9 years ago
Overview
Brief Summary
Early intervention and resuscitation based upon a lot of clinical, laboratory findings make a big difference regarding outcome in poly trauma patients, the study uses the dynamic lactate change and the difference between arterial and venous CO2, oxygen tension or content as indicators for tissue perfusion.
Detailed Description
Poly trauma patients have high incidence of mortality and morbidity in spite of improvements and advances in facilities. However, no doubt that early resuscitation and interventions make a big difference upon the overall outcome. A lot of methods, indices, laboratory and biomarkers have been utilized to evaluate the progress and quality of resuscitation and the early hospital interventions in such group of critically ill patients including central venous pressures, urine output, mixed venous oxygen saturation, and gastric tonometry. Most of recent means focus upon the regional tissue perfusion rather than global, however some researches have tried the difference between arterial and venous CO2,oxygen tension or content ( Pv -a co2\& Pa -v O2 ) in addition to dynamic changes in lactate(3) as predictors for tissue perfusion in sepsis patients after establishment of sepsis campaign (bundle).
Investigators
Emad Zarief , MD
Lecturer of Anesthesia and critical care Medicine
Assiut University
Eligibility Criteria
Inclusion Criteria
- •multiple trauma patients Adult patients
Exclusion Criteria
- •cardiac renal chronic chest disease diabetic more than 3 years
Outcomes
Primary Outcomes
the difference between partial pressure of oxygen in arterial and venous blood
Time Frame: 6 hours
serum level of lactate and its changes
Time Frame: 6 hours
as an index for tissue oxygenation
the difference between partial pressure of carbon dioxide in arterial and venous blood
Time Frame: 6 hours
Secondary Outcomes
- Kidney function(72 hours)
- duration of stay in the critical care unit(72 hours)
- hemodynamic stability including pulse rate and mean arterial blood pressure(72 hours)