co2 Gap and co2/o2 Ratio in Liver Transplant Patients

Not Applicable

• Conditions: Liver Transplantation
• Interventions: Diagnostic Test: Fluid challenge

• Registration Number: NCT03374579
• Lead Sponsor: Kasr El Aini Hospital

Brief Summary

finding surrogate to co to trace the effect of preload challenge would make the test more applicable without the need of advanced hemodynamic monitors,suggested that co2 gap can be used to detect FR after mini fluid challenge and fluid bolts .

Detailed Description

use of carbon dioxide gap and arterio venous oxygen content to trace the effect of preload challenge by giving via a specific venous line , first 150 ml is infused over one minute, after stroke volume at one minute measure the remaining 350 ml is infused over 14 minutes at constant rate , the fluid challenge performed with albumin 5% , fluid responsiveness is an increase in stroke volume by 15% after infusion of 500ml albumin 5%.

Objectives is to investigate the ability of VA-co2 gap and gap/ ratio to predict the hemodynamic response to mini fluid challenge, and to compare the validity of VA-co2 gap and gap/ratio with svo2 for prediction of fluid responsiveness.

Study Timeline

• Study Start: 2017-06-12
• Study First Submitted: 2017-12-11
• Study First Submitted QC: 2017-12-14
• Study First Posted: 2017-12-15
• Status Verified: 2018-03
• Last Update Submitted: 2018-03-27
• Last Update Posted: 2018-03-29
• Primary Completion: 2018-05-12
• Study Completion: 2018-09-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• patients post liver transplantation
• serum lactate >2mmol/L

Exclusion Criteria

• age less than 18 years
• patients with fulminant liver failure.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
CO2 gap	Fluid challenge	The patients will receive fluid bolus and observe changes in co2 gap and gap/ ratio in them.

Primary Outcome Measures

Name	Time	Method
co2gap	30 minuets after fluid bolus	Difference between arterial and venous co2 gap

Secondary Outcome Measures

Name	Time	Method
Stroke volume	Baseline 30 minutes after Icu admission, 1 minutes after mini fluid challenge , 30 minutes after fluid bolus	Stroke volume assessed by cardiometry

Trial Locations

Locations (2)

Cairo University Medical School; 🇪🇬 Cairo, Egypt

Kasralainy hospital; 🇪🇬 Cairo, Egypt