Objective Grading of Intraocular Inflammation in Uveitis Using Optical Coherence Tomography
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Enrollment
- 125
- Locations
- 1
- Primary Endpoint
- Identification & Measurement of Anterior Chamber Cells
Study Overview
Brief Summary
The goal of this study is to determine if it's possible to use a high resolution imaging device called optical coherence tomography (OCT) to develop an unbiased, standard method of counting and categorizing the various types of cells and proteins found in an eye condition called anterior uveitis. Anterior uveitis is a type of inflammation in the eye that can be caused by many different diseases of the body.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Cross Sectional
Eligibility Criteria
- Ages
- 5 Years to 85 Years (Child, Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Uveitis Group: Eyes with active intraocular inflammation and a clinical diagnose of spondyloarthritis/HLA-B27 associated anterior uveitis, Juvenile Idiopathic Arthritis (JIA) associated chronic anterior uveitis, Herpes Simplex Virus (HSV) anterior uveitis, Birdshot chorioretinitis, Behcet disease uveitis, sarcoidosis associated uveitis, uveitis of any additional type, or uveitis masquerade.
- •Posterior Vitreous Detachment Group: Eyes with vitreous floaters and posterior vitreous detachment (PVD).
- •Healthy/Control Group: Healthy eyes with no history of uveitis, PVD, or previous eye surgery.
Exclusion Criteria
- •Inability to give informed consent.
- •Inability to maintain stable fixation for OCT imaging.
- •Inability to commit to required visits to complete the study.
- •Pregnancy and breastfeeding.
Outcomes
Primary Outcomes
Identification & Measurement of Anterior Chamber Cells
Time Frame: Day 1
Anterior Chamber (AC) cells will be identified from OCT images by computer algorithms. AC cell number counted by OCT will be correlated with slit lamp grading. Cell size \& other characteristics identified from OCT images will be associated with different uveitis diagnostic categories. The Standardization of Uveitis Nomenclature (SUN) grading system (scale: 0 = none to 4+ = severe) will be used to compare OCT-derived quantification against slit-lamp grading performed by attending physicians.
Secondary Outcomes
- Measure of Vitreous Cells(Day 1)
- Measure of AC Flare(Day 1)
- Measure of Keratic Precipitates(Day 1)
- Measurement of Vitreous Haze(Day 1)
Investigators
David Huang
Professor
Oregon Health and Science University