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Quantification & Classification of Inflammatory Cells in Uveitis Using OCT

Recruiting
Conditions
Anterior Uveitis (AU)
Birdshot Chorioretinitis
Herpes Simplex Virus
Juvenile Idiopathic Arthritis (JIA)
Behcet Disease
Spondyloarthritis (SA)
Sarcoidosis
Posterior Vitreous Detachment
Registration Number
NCT07065747
Lead Sponsor
Oregon Health and Science University
Brief Summary

The goal of this study is to determine if it's possible to use a high resolution imaging device called optical coherence tomography (OCT) to develop an unbiased, standard method of counting and categorizing the various types of cells and proteins found in an eye condition called anterior uveitis. Anterior uveitis is a type of inflammation in the eye that can be caused by many different diseases of the body.

Detailed Description

Not available

Recruitment & Eligibility

Status
RECRUITING
Sex
All
Target Recruitment
125
Inclusion Criteria
  1. Uveitis Group: Eyes with active intraocular inflammation and a clinical diagnose of spondyloarthritis/HLA-B27 associated anterior uveitis, Juvenile Idiopathic Arthritis (JIA) associated chronic anterior uveitis, Herpes Simplex Virus (HSV) anterior uveitis, Birdshot chorioretinitis, Behcet disease uveitis, sarcoidosis associated uveitis, uveitis of any additional type, or uveitis masquerade.
  2. Posterior Vitreous Detachment Group: Eyes with vitreous floaters and posterior vitreous detachment (PVD).
  3. Healthy/Control Group: Healthy eyes with no history of uveitis, PVD, or previous eye surgery.
Exclusion Criteria
  1. Inability to give informed consent.
  2. Inability to maintain stable fixation for OCT imaging.
  3. Inability to commit to required visits to complete the study.
  4. Pregnancy and breastfeeding.

Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Identification & Measurement of Anterior Chamber CellsDay 1

Anterior Chamber (AC) cells will be identified from OCT images by computer algorithms. AC cell number counted by OCT will be correlated with slit lamp grading. Cell size \& other characteristics identified from OCT images will be associated with different uveitis diagnostic categories. The Standardization of Uveitis Nomenclature (SUN) grading system (scale: 0 = none to 4+ = severe) will be used to compare OCT-derived quantification against slit-lamp grading performed by attending physicians.

Secondary Outcome Measures
NameTimeMethod
Measure of Vitreous CellsDay 1

Vitreous cells will be identified from OCT images. Counting of vitreous cells will be done by computer algorithms. Since vitreous cells are not formally graded or quantified in the SUN system, physician grading will be described as rare, few, moderate, numerous, or sheets and compared against the OCT-derived measurements.

Measure of AC FlareDay 1

OCT signal of the aqueous humor will be analyzed and correlated with slit lamp grading by the attending physician. The SUN grading system (scale: 0 to 4+) will be used.

Measure of Keratic PrecipitatesDay 1

Keratic precipitates (KPs) will be identified from OCT images. The size of the KPs will be compared across different uveitis diagnostic categories. There is no formal grading system for KPs. The investigators will use the typical qualitative assessments of morphology, distribution, and density. For morphology, cells will be described as fine, mutton-fat, stellate, or pigmented. Distribution patterns will be described as Arlt's Triangle, diffuse, central, or ring-shaped. Density will be described as few, moderate, or numerous.

Measurement of Vitreous HazeDay 1

OCT signal of the vitreous clarity will be compared against clinical grading of vitreous haze. The National Eye Institute (NEI) Grading Scale will be used. Grading will be documented on a scale of 0 = no haze to 4+ = severe haze.

Trial Locations

Locations (1)

Casey Eye Institute - Oregon Health & Science University

🇺🇸

Portland, Oregon, United States

Casey Eye Institute - Oregon Health & Science University
🇺🇸Portland, Oregon, United States

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