NL-OMON56912尚未招募不适用
*Translating the Adipose Tissue-liver axis in Metabolic dysfunction associated SteatoHepatitis: finding inflammatory therapeutic targets and biomarkers* - translATe-MASH
Zuyderland Medisch Centrum0 个研究点目标入组 308 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 308
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •subject must be eligible for abdominal surgery (bariatric, gallbladder or
- •other) and between 18 and 75 years of age. The additional inclusion criterion
- •for the control group will be BMI<25 and for the overweight/obese patients
排除标准
- •- Evidence of MASLD (based on biopsy or fibroscan measurements) for lean
- •(BMI<25) control individuals
- •- Alcohol consumption > 2 per day for women; >3 per day for men
- •- Drug abuse
- •- Known viral hepatitis or other infection
- •- Hepatic cancer
- •- Elevated CRP levels (>10)
- •- Diabetes mellitus type 1 or other autoimmune diseases
- •- Use of anti-inflammatory drugs (specifically corticosteroids)
- •- For patients without type 2 diabetes: use of anti-diabetes drugs due to their
- •known effect on inflammation (e.g. metformin, GLP1 mimetics)
- •- - Pregnancy or breastfeeding
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