NCT05539677
招募中
不适用
Analysis of the Immunogenetic Profile of Patients With Aggressive Course of Malignant Neoplastic Process Resistant to the Standard Treatment Approaches: a Translational Study
N.N. Petrov National Medical Research Center of Oncology1 个研究点 分布在 1 个国家目标入组 1,000 人1998年9月
概览
- 阶段
- 不适用
- 干预措施
- 未指定
- 疾病 / 适应症
- Malignant Solid Tumors
- 发起方
- N.N. Petrov National Medical Research Center of Oncology
- 入组人数
- 1000
- 试验地点
- 1
- 主要终点
- Progression in 3 mo
- 状态
- 招募中
- 最后更新
- 去年
概览
简要总结
The investigators will collect biosamples of patient blood and tumour tissue for further immunological analysis of blood cell subpopulations, immunosupressive factors concentration, HLA expression an lymphocytes and tumour tissue, and and cancer testis antigenes expression on tumour cells, as well as clinical data on patient's stage, therapy, response and demographics. Possible prognostic and predictive dynamic biomarkers will be discovered for individualisation of treatment strategies
研究者
入排标准
入选标准
- •Signed inform consent
- •Histolgically verified solid tumour
- •Receiving systemic therapy for neoplasm
- •Has archival tumour tissue
- •Provide biosamples with living tumour tissue or blood samples for immunologic assessment
排除标准
- •Concurrent Lymphoprolipherative disorder
- •Patients after stem cell or bone marrow thansplantation
- •Incomplete informaton on previous cancer history or medical history
- •Patients with known primary immunodeficiency
- •Patients receiving immunosupressive therapy for concurrent illness
- •Pregnant patients
结局指标
主要结局
Progression in 3 mo
时间窗: 3 month
Presence of disease progression within 3 mo from sample aquisition
次要结局
- Overall survival (OS)(Up to 5 years)
- Response rate(During the intervention)
- Progression free survival(Up to 5 years)
研究点 (1)
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