Study on the mechanism of Qingchangxiaopi Decoction and UC large intestine damp-heat syndrome from the activation of LPDC through TLR5-IRF4 pathway to mediate intestinal inflammatio

Phase 1

• Conditions: lcerative Colitis

• Registration Number: ITMCTR2200005909
• Lead Sponsor: Dongguan Hospital of Guangzhou University of Chinese Medinine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Pending
• Sex: Male
• Target Recruitment: Not specified

Inclusion Criteria

?The healthy subjects were inquired about medical history and physical examination, excluded cardiovascular and cerebrovascular diseases, diabetes, hypertension, hyperlipidemia and other medical history, and excluded intestinal organic diseases.
?UC patients who meet the diagnostic criteria;
?Meet the criteria for UC in the light to moderate activity period;
?Those who signed the informed consent.

Exclusion Criteria

?Patients with severe heart, liver, kidney and other major organ diseases, hematopoietic system, nervous system or mental diseases;
?Patients with serious complications such as local stricture, toxic megacolon, intestinal obstruction, colon cancer, rectal cancer, intestinal perforation and anal disease;
?Reluctance to sign informed consent and collaborators.

Study & Design

• Study Type: Interventional study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mayo score;

Secondary Outcome Measures

Name	Time	Method
disease remission rate;single symptom treatment effect;erythrocyte sedimentation rate;High - sensitivity C - Reactive protein;The quality of life of inflammatory bowel disease questionnaire;