NCT01549483已完成不适用
Differences in Small Airways Disease Between Asymptomatic and Symptomatic Subjects With Airway Hyperresponsiveness
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 45
- 试验地点
- 1
- 主要终点
- Peripheral airway resistance measured with impulse oscillometry (IOS)
研究概览
简要总结
The purpose of this study is to study differences in small airways (<2mm) parameters in asthma patients, subjects with asymptomatic airway hyperresponsiveness and healthy controls.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- •Use of inhaled or oral steroids, antihistamines, nedocromil, theophylline, leukotrien antagonists or long-acting beta-agonists for at least three weeks before the start of the study.
- •Any disease that may affect the outcome of the study as judged by the Investigator.
- •FEV1 <1.2 liter.
结局指标
主要结局
Peripheral airway resistance measured with impulse oscillometry (IOS)
时间窗: visit 1
Difference between resistance at 5 Hz (R5) and resistance at 20 Hz (R20) (R5-20).
次要结局
- mRNA expression in nasal epithelium(visit 2)
- Small airway parameters(visit 1)
- Peripheral airway resistance measured during provocation test(visit 2)
研究者
Maarten van den Berge
Dr.
University Medical Center Groningen
研究点 (1)
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