Differences in small airways disease between asymptomatic and symptomatic subjects with airway hyperresponsiveness - AHR and small airways

niversitair Medisch Centrum Groningen0 个研究点目标入组 45 人开始时间: 待定最近更新: 2024年5月6日

适应症

试验速览

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•Inclusion criteria for asymptomatic subjects without AHR :
•Age between 18 and 65 years.
•FEV1 > 80% predicted post bronchodilator.
•PC20 methacholine <= 8 mg/ml.
•No history of asthma or previous use of asthma medication.;Inclusion criteria for asymptomatic subjects without AHR :
•Age between 18 and 65 years.
•FEV1 > 80% predicted post bronchodilator.
•PC20 methacholine >8 mg/ml.
•No history of asthma or previous use of asthma medication.;Inclusion criteria for patients with asthma:
•Age between 18 and 65 years.
•FEV1 > 80% predicted.
•PC20 methacholine <=8 mg/ml.
•Doctor's diagnosis of asthma
•No history of COPD

•Use of inhaled or oral steroids, antihistamines, nedocromil, theophylline, leukotrien antagonists or long-acting beta-agonists for at least three weeks before the start of the study.
•Any disease that may affect the outcome of the study as judged by the Investigator.
•FEV1 <1.2 liter.
•A respiratory tract infection within 4 weeks prior to the start of the study.

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