Associations Between Cardiac Autoantibodies and Changes in Arterial Stiffness in Youth with Type 1 Diabetes
Recruiting
- Registration Number
- TCTR20240425006
- Lead Sponsor
- Faculty of Medicine Khon Kaen University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
1.Diagnosed with type 1 diabetes per American Diabetes Association criteria, 2. Age at diagnosis equal or less than 18 years, 3. Diabetes duration of more than 1 year, 4. Regular follow up at Pediatric Diabetes Clinic, KKU hospital
Exclusion Criteria
1. HbA1c more than 13%, 2. Creatinine more than 1.5 mg/dL, 3. Smoking, 4. Hypertension, 5. Receive medications that affect insulin resistance or arterial function, such as systemic/inhale glucocorticoids, oral antihyperglycemic drug, immunosuppressive drugs, and atypical antipsychotic drugs, in the 2 months, 5. Pregnancy, 6. Lactation, 7. Incomplete medical record, 8. Diabetic ketoacidosis in the past 2 months, 9. Other chronic illness affecting arterial function
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Changes in carotid-femoral pulse wave velocity At 12-24 months carotid-femoral pulse wave velocity,Cardiac autoantibodies At baseline Cardiac autoantibodies: FL-MYH6, S2-MYH6, FL-MYH7
- Secondary Outcome Measures
Name Time Method -terminal pro-B type natriuretic peptide (NT-proBNP) At 3-6 months before the study serum NT-proBNP concentration