cardiovascular health effects of flavanol rich chocolate

Completed

Conditions: endothelial dysfunction
vascular health
10047079

Registration Number: NL-OMON34562

Lead Sponsor: Wageningen Universiteit

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 44

Inclusion Criteria

Caucasian Male
45-70y
BMI between 25 and 32 kg/m2

Exclusion Criteria

Urine glucose concentrations outside normal ranges (>0,25 g/l)
Fasting blood glucose >7.0 mmol/L)
Systolic Bp >160 mmHg or diastolic Bp>100 mmHg
Blood Hb values < 8.4 mmol/L
Allergic to cow milk, dairy products or chocolate
Vegetarian
Tobacco smoker
Diagnosed with any long-term medical condition (e.g., diabetes, hemophilia, cardiovascular disease, anemia, gastrointestinal disease, renal failure)
No use of medication or food supplements known to interfere with: glucose homeostasis, blood pressure, Inflammation
If the participant don*t want to be informed about unexpected findings during the screening or study

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Vascular measurements: Flow-mediated dilatation (FMD), Pulse Wave Analysis<br /><br>(PWA) of the radial artery and Blood pressure</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Blood hematocrite and complete blood count<br /><br>Plasma epicatechins<br /><br>Peripheral blood mononuclear cell (PBMC) protein and gene expression profiles<br /><br>Cell surface activation markers of white blood cells<br /><br>Plasma markers of endothelial function, inflammation and oxidative stress<br /><br>Urine markers of oxidative stress and kidney function<br /><br><br /><br><br /><br></p><br>