Effect of Acupuncture regulating macrophage polarization to alleviate sepsis-induced muscle atrophy - a prospective cohort study

Not Applicable

• Conditions: Sepsis-induced myopathy

• Registration Number: ITMCTR1900002636
• Lead Sponsor: Department of Intensive Care Unit, the First Affiliated Hospital of Guangzhou University of Chinese Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

1. Aged 18 to 85 years old;
2. Meet the criteria of Sepsis-320which define sepsis as infection + SOFA >=2 points within the first 24 hour;
3. The first time admitted to ICU and expect to survive within the first 48 hours;
4. Informed consent signed by the patient or immediate family member (next to kin);
5. The Rectus Femoris cross-sectional area (RFcsa) decreased more than 9.24%21 after ICU admission;
6. Survival within ICU stay.

Exclusion Criteria

1. A confirmed positive result of pregnancy or urine beta-HCG test;
2. The questionnaire(MRC-SS/FIM/consent form) could not be completed due to cognitive abnormalities;
3. A newly diagnosed primary neuromuscular disease when admitted to the hospital;
4. Patients who have leg amputationpelvic/femoral fractures or knee/hip replacement that could not complete the measure of RFcsa;
5. Malnutrition (BMI less than 18.5 kg/m2) or cachexia;
6. Patients with metastatic tumors (PD) or ongoing chemotherapy;
7. Patients with cardiorespiratory arrest or imminent death
8. Patients with long-term corticoid treatment;
9. Can't walk independently before sepsis onset;
10. ICU length of stay <7 days;
11.Sepsis has been onset more than 5 days before ICU admission;
12. Therapy withdrawal and consent refusal.

Study & Design

• Study Type: Observational study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
expression levels of serum myostatin;Incidence of Time to Event;rectus femoris cross-sectional area;MRC-SS score;Functional Independence Measure;

Secondary Outcome Measures

Name	Time	Method
case of re-admission of hospital;times of re-entered the ICU;days of hospital stay;duration of invasive/non-invasive mechanical ventilation;ICU maintain days;case of re-entered the ICU;