Role of HVNI in Severe Chest Trauma

Not Applicable

Not yet recruiting

• Conditions: Chest Trauma
• Interventions: Device: High Velocity Nasal Insufflation

• Registration Number: NCT05692076
• Lead Sponsor: Assiut University

Brief Summary

to compare the respiratory complications in patient managed with high velocity nasal insufflation versus patients managed with conventional low flow oxygen in patients with severe chest trauma

Detailed Description

* Chest trauma are associated with significant morbidity and mortality due to respiratory failure and pneumonia.

* The two main goals of therapy are pain management and pulmonary care and support. There is strong evidence for providing good analgesia to facilitate volume expansion treatment and chest physiotherapy, aiming for deep breathing and effective cough to reduce secretions and prevent the atelectasis.

* Oxygen supplementation is often included as supportive therapy added to bundles of care for patients of chest trauma with rib fractures.

High -velocity nasal insufflation (HVNI ) was first developed for neonates and has gained increasing use in adult patients for prevention and treatment of respiratory failure. High-flow humidified oxygen with flow rates from 30 to100 L/min with high fraction of inspired oxygen( FiO2) is able to be delivered. Positive end-expiratory pressure can be generated, preventing alveoli collapse. The washout of carbon dioxide (CO2)and replacement with enriched O2 purportedly decreases work of breathing and increases breathing effectiveness.

* Routine tests for chest injuries include chest X-rays and computed tomography (CT) scans. Ultrasound has the advantages of being inexpensive, readily available and being free of ionizing radiation .

* In thoracic trauma cases, ultrasonography of the lungs is valuable for evaluating various chest diseases, including chest wall haematoma and fractures, pleural cavity involvement with pleural effusion, haemothorax, and pneumothorax. The ultrasound can also assess the reduce in lung aeration by changing the lung surface and generating distinct patterns as in pulmonary contusions and compression atelectasis.

Study Timeline

• Status Verified: 2023-01
• Study First Submitted: 2023-01-11
• Study First Submitted QC: 2023-01-11
• Last Update Submitted: 2023-01-11
• Study Start: 2023-01-20
• Study First Posted: 2023-01-20
• Last Update Posted: 2023-01-20
• Primary Completion: 2025-03-20
• Study Completion: 2025-09-20

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 86

Inclusion Criteria

• Chest trauma patients with lung injury confirmed by ct imaging

  • the age from 15-55 years old
  • No indication of mechanical ventilation at the time of admission to the intensive care unit

Exclusion Criteria

• • Patients < 15years old

  • requiring endotracheal intubation and mechanical ventilation immediately on admission for any cause
  • facial fractures or base of skull fractures
  • Who did not receive a chest computed tomography (CT) scan
  • Glasgow Coma Scale <10
  • Massive surgical emphysema
  • COPD Patients ( chronic obstructive pulmonary disease )

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
HVNI group	High Velocity Nasal Insufflation	Patients will receive high velocity nasal insufflation therapy
Control group	High Velocity Nasal Insufflation	Patient will receive conventional oxygen therapy via nasal prongs , normal oxygen mask or venturi mask

Primary Outcome Measures

Name	Time	Method
Incidence of atelectasis in chest trauma patients	3 years	Incidence of atelectasis in chest trauma patients using the chest ultrasound measured by lung consolidation score.

Secondary Outcome Measures

Name	Time	Method
respiratory complications,hospital stay and Comfort levels	3 years	Other respiratory complications as hypoxemia and pneumonia.; * Need for intubation and mechanical ventilation; * Length of ICU and hospital stay.; * Comfort levels with different levels of oxygen delivery measured by Likert scale.