Sedation and Guided Education for Depression Study

Not Applicable
Not yet recruiting
Conditions
Registration Number
NCT06705270
Lead Sponsor
Stanford University
Brief Summary

The goal of this clinical trial is to understand how patient education surrounding a one-time, consciousness-altering medical intervention impacts the antidepressant response to the intervention in adults with major depressive disorder. In this study, the consciousness-altering medical intervention is a single infusion of propofol, an intravenous anesthetic ...

Detailed Description

Not available

Recruitment & Eligibility

Status
NOT_YET_RECRUITING
Sex
All
Target Recruitment
20
Inclusion Criteria
  • Diagnosis of major depressive disorder of at least moderate severity
  • Able to read, understand, and provide written informed consent
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Exclusion Criteria
  • Pregnant or breastfeeding
  • Certain substance use disorders
  • Daily use of opioids and/or benzodiazepines
  • History of psychosis, schizophrenia, or schizoaffective disorder
  • Body mass index greater than 35 kg/m2
  • Obstructive sleep apnea that is moderate and untreated, or severe
  • Any gastrointestinal condition placing the patient at significant risk of aspiration
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Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Primary Outcome Measures
NameTimeMethod
Depression severityFrom enrollment to 28 days after treatment

The 16-item Quick Inventory of Depressive Symptomatology Self-Report (QIDS-SR-16) assesses the severity of depressive symptoms experienced by an individual. Items are self-rated on a 4-point scale tailored to each depression symptom. Higher total scores indicate greater depression severity.

Secondary Outcome Measures
NameTimeMethod
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