Sedation and Guided Education for Depression Study
- Conditions
- Registration Number
- NCT06705270
- Lead Sponsor
- Stanford University
- Brief Summary
The goal of this clinical trial is to understand how patient education surrounding a one-time, consciousness-altering medical intervention impacts the antidepressant response to the intervention in adults with major depressive disorder. In this study, the consciousness-altering medical intervention is a single infusion of propofol, an intravenous anesthetic ...
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 20
- Diagnosis of major depressive disorder of at least moderate severity
- Able to read, understand, and provide written informed consent
- Pregnant or breastfeeding
- Certain substance use disorders
- Daily use of opioids and/or benzodiazepines
- History of psychosis, schizophrenia, or schizoaffective disorder
- Body mass index greater than 35 kg/m2
- Obstructive sleep apnea that is moderate and untreated, or severe
- Any gastrointestinal condition placing the patient at significant risk of aspiration
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Depression severity From enrollment to 28 days after treatment The 16-item Quick Inventory of Depressive Symptomatology Self-Report (QIDS-SR-16) assesses the severity of depressive symptoms experienced by an individual. Items are self-rated on a 4-point scale tailored to each depression symptom. Higher total scores indicate greater depression severity.
- Secondary Outcome Measures
Name Time Method