The effect of azithromycin in patients with COPD and chronic productive cough.

Phase 3

• Conditions: chronic bronchitis and emphysema.; COPD; 10006436

• Registration Number: NL-OMON31487
• Lead Sponsor: Isala Klinieken

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 84

Inclusion Criteria

1. Patients > 40 years old, in our outpatient clinic with chronic cough and COPD (gold 2-4).
2. Chronic cough is defined as a cough > 12 weeks duration, 2 years in a row.
3. Analysed for bronchiectasis prior to participation.

Exclusion Criteria

1. Use of i.v. or oral corticosteroids and or antibiotics for an exacerbation 3 weeks before inclusion
2. Patients suffering from other relevant lung diseases.
3. Clinically relevant abnormal laboratory values suggesting an unknown disease requiring further clinical evaluation.
4. Liver disease, (ALAT and/or ASAT levels two or more times the upper limit of normal).
5. Pregnancy or lactation.
6. Use of macrolides the last 6 weeks prior to inclusion.
7. Allergy or intolerance to macrolides.
8. Other research medication started 2 months prior to inclusion.

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>LCQ (leicester cough questionnaire)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Short form 36, SGRQ.<br /><br>FEV1, VC (spirometry), inflammatory markers sputum, microbiology sputum.</p><br>