Changes in Circulating Sclerostin Levels During Acute Postsurgical Hypoparathyroidism
- Conditions
- Hypoparathyroidism Postprocedural
- Interventions
- Registration Number
- NCT04146259
- Lead Sponsor
- University of Athens
- Brief Summary
To investigate changes in sclerostin levels following acute post-thyroidectomy hypoparathyroidism
- Detailed Description
Female patients with thyroid disorders, referred to the Department of Head and Neck Surgery, at Metaxa Anti-Cancer Hospital of Piraeus, for total thyroidectomy.
Based on the development of biochemical hypocalcemia (cCa \< 8.4 mg/dl), subjects were divided into 2 groups: Group A: without postsurgical hypoparathyroidism that served as controls and group B: subjects, with acute postsurgical hypoparathyroidism.
Blood collections were performed in the morning after an overnight fast, in at least 3 different time points; preoperatively, 1st postoperative day and 7th postoperative day for the detrmination of sclerostin levels
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 109
- Indication for total thyroidectomy
- parathyroid disorders, chronic kidney disease (eGFR< 60 ml/min), treatment with antiosteoporosis drugs, rheumatic disease and history of long term (>1 month) or current corticosteroid use
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Group B calcium carbonate and alphacalcidol Post-surgical hypoparathyroidism
- Primary Outcome Measures
Name Time Method change in circulating serum sclerostin levels (pmol/L) during the observation period 7 days change in circulating serum sclerostin levels (pmol/L)during the observation period
- Secondary Outcome Measures
Name Time Method the between groups difference in % changes of circulating sclerostin 7 days the between groups difference in % changes of circulating sclerostin
Trial Locations
- Locations (1)
Symeon Tournis
🇬🇷Athens, Greece