Changes in Circulating Sclerostin Levels During Acute Postsurgical Hypoparathyroidism
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 109
- 试验地点
- 1
- 主要终点
- change in circulating serum sclerostin levels (pmol/L) during the observation period
研究概览
简要总结
To investigate changes in sclerostin levels following acute post-thyroidectomy hypoparathyroidism
详细描述
Female patients with thyroid disorders, referred to the Department of Head and Neck Surgery, at Metaxa Anti-Cancer Hospital of Piraeus, for total thyroidectomy.
Based on the development of biochemical hypocalcemia (cCa < 8.4 mg/dl), subjects were divided into 2 groups: Group A: without postsurgical hypoparathyroidism that served as controls and group B: subjects, with acute postsurgical hypoparathyroidism.
Blood collections were performed in the morning after an overnight fast, in at least 3 different time points; preoperatively, 1st postoperative day and 7th postoperative day for the detrmination of sclerostin levels
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Indication for total thyroidectomy
排除标准
- •parathyroid disorders, chronic kidney disease (eGFR< 60 ml/min), treatment with antiosteoporosis drugs, rheumatic disease and history of long term (>1 month) or current corticosteroid use
研究组 & 干预措施
Group B
Post-surgical hypoparathyroidism
干预措施: calcium carbonate and alphacalcidol (Drug)
结局指标
主要结局
change in circulating serum sclerostin levels (pmol/L) during the observation period
时间窗: 7 days
change in circulating serum sclerostin levels (pmol/L)during the observation period
次要结局
- the between groups difference in % changes of circulating sclerostin(7 days)
研究者
Symeon tournis
Senior Research Fellow
University of Athens