NCT00919243已完成4 期
Prednisone Versus Allopurinol for Symptomatic Heart Failure Patients With Hyperuricemia
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Change from baseline in uric acid level
研究概览
简要总结
Hyperuricemia is a very common finding in patients with heart failure. It is usually related to diuretic use and deteriorated renal function. The recently evidence showed that uric acid (UA) lowering therapy may improve clinical status in symptomatic heart failure patients with hyperuricemia. In their clinical practice, the investigators found that glucocorticoids could dramatically lower UA while improving renal function. Thus the investigators design this randomized head to head study to test our hypothesis that prednisone have the same efficacy to allopurinol on lowering UA and could improve renal function at the same time.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18-70 years old
- •NYHA Class III-IV
- •EF =< 40%
- •Uric acid => 9.5 mg/dL
排除标准
- •Acute gouty arthritis
- •Any condition (other than CHF) that could limit the use of prednisone or allopurinol
- •Any concurrent disease likely to limit life expectancy.
- •Active myocarditis, or an obstructive or restrictive cardiomyopathy
- •Heart Attack, Stroke, Unstable Angina or Cardiac surgery within previous 3 months
研究组 & 干预措施
prednisone
Experimental
干预措施: prednisone (Drug)
allopurinol
Active Comparator
干预措施: allopurinol (Drug)
结局指标
主要结局
Change from baseline in uric acid level
时间窗: 4 weeks
次要结局
- Change from baseline in creatinine clearance rate(4 weeks)
- Daily urine volume(4 weeks)
- Body weight(4 weeks)
- patient assessed dyspnea and physician assessed global clinical status(4 weeks)
- 6-minute walking distance(4 weeks)
- NYHA functional class(4 weeks)
研究者
研究点 (1)
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