Prognostic Factors Associated With Postoperative Cognitive Dysfunction After Surgery
- Conditions
- Postoperative Cognitive Dysfunction
- Registration Number
- NCT03443440
- Lead Sponsor
- Milton S. Hershey Medical Center
- Brief Summary
A longitudinal observational study examining preoperative, intraoperative and postoperative factors associated with Postoperative Cognitive Dysfunction in patients older than the age of 50.
- Detailed Description
A longitudinal observational study examining factors associated with Postoperative Cognitive Dysfunction (POCD) utilizing a computerized neurocognitive battery. In addition, investigators seek to assess the presence of pre-existing psychiatric disorders and chronic pain to determine their relationship with POCD. The study will seek to compare the rates of POCD in previously published literature with performance on a computerized neurocognitive battery. In addition, the study will seek to determine preoperative, intraoperative and postoperative factors associated with POCD by comparing these variables to performance on a computerized neurocognitive battery.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 57
- Ability to perform informed consent
- Age greater than 50 years old
- Ability to read and understand English
- Undergoing elective surgery with general or neuraxial anesthesia
- Patients who do not meet above defined criteria, patients from vulnerable populations (adults unable to consent, pregnant women, prisoners), patients refusing informed consent and participation in the study.
- A previous history of the following medical conditions: dementia of any kind (vascular dementia, Alzheimer's disease, organic brain disease with documented cognitive deficits, severe traumatic brain injury, Parkinson's disease, senility)
- Physical impairment impairing their ability to perform neurocognitive testing incl. essential tremor, loss of upper extremity motor function, blindness, or severe hearing loss)
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Change in performance on the CogState Brief Battery Change from baseline on the Cogstate Brief Battery score at postoperative Day 30-40. Neurocognitive Test. Detection Task (Score: normal - abnormal), One Card Learning Task (Score: normal - abnormal) One Back Task (Score normal - abnormal) Identification Task (Score normal - Abnormal) Scores are based on normal distributed population data. Scores are measured on a linear scale with no maximum score. Research subjects will also act as their own control based on baseline performance in this longitudinal study.
- Secondary Outcome Measures
Name Time Method Change in performance on the Beck Clinical Depression Inventory (BDI) Change in baseline on the Beck Clinical Depression Inventory at postoperative Day 30-40. Test for symptoms of clinical depression. (Scored: 1 to \>40 from normal to extreme depression)
Barthel Index of Activities of Daily Living Change in baseline on the Barthel Index at postoperative Day 30-40. Scale to assess independent function of patient. Components assessing continence, mobility, transfer skills, grooming, hygiene, feeding, bathing, stairs and dressing. (Scored: 0-2, dependent - completely independent) Total Score 0-20 (fully dependent - fully independent)
Change in performance on the Short-Form McGill Pain Questionnaire (SF-MPQ-2) Change in baseline on the SF-MPQ-2 at postoperative Day 30-40. Test of presence of chronic pain (Scored 0-3(severe)) Validates the sensory component of neuropathic or chronic pain, a visual analog scale (Scored: no pain to worst possible pain) and a Present Pain Intensity (Scored: 0-5 (worst)).
Trial Locations
- Locations (1)
Penn State Health Milton S. Hershey Medical Center
🇺🇸Hershey, Pennsylvania, United States