Developing Biomarkers in Pancreatic Cancer
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 53
- 试验地点
- 3
- 主要终点
- Cellular localization of BRCA1 as a predictor of response to cytotoxic agents or radiotherapy
研究概览
简要总结
RATIONALE: Studying samples of tissue in the laboratory from patients with cancer may help doctors identify and learn more about biomarkers related to cancer. It may also help doctors predict how patients will respond to treatment.
PURPOSE: This research study is studying biomarkers in patients with pancreatic cancer.
详细描述
OBJECTIVES:
- To determine whether the cellular localization of BRCA1 can predict how patients with pancreatic cancer will respond to cytotoxic agents (e.g., fluorouracil or gemcitabine hydrochloride) or radiotherapy.
- To identify pre-treatment markers that can be used to correlate with clinical outcomes of survival and recurrence.
- To determine if a method of extracting and identifying secreted cytokines and growth factors from biopsy tissue can now be applied to the pancreatic cancer population.
OUTLINE: Tissue samples from biopsies performed during pancreatectomy are collected from the Vanderbilt Ingram Cancer Center Human Tissue Acquisition Core for laboratory biomarker studies. Proteins secreted by cancer cells and/or cancer-associated cells are studied by extracting and identifying secreted cytokines and growth factors from biopsy tissue. The integrity of the DNA repair pathway in pancreatic cancer is analyzed by Rad51 and phosphorylated DNA-PK foci formation. Markers are correlated with clinical outcome.
Patients are followed for recurrence, relapse, and death from disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Cellular localization of BRCA1 as a predictor of response to cytotoxic agents or radiotherapy
时间窗: following collection of all pancreatic tissue specimens and patient outcome data
Examine the location of BRCA1 in the cells and determine if this location predicts patient response to the chemotherapy drugs given
次要结局
- Correlation of pre-treatment markers with survival and recurrence(at expiration date of final patient enrolled)
- Application of a method of extracting and identifying secreted cytokines and growth factors from biopsy tissue to the pancreatic cancer population(upon collection of pancreatic tissue for each patient)
研究者
A Bapsi Chakravarthy, MD
Associate Professor; Radiation Oncologist
Vanderbilt-Ingram Cancer Center