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Clinical Trials/NCT01805193
NCT01805193
Completed
Not Applicable

Validation of Computed Tomography Myocardial Perfusion Imaging Using Quantification of Myocardial Blood Flow by Positron Emission Tomography With 15O-water

University of Edinburgh1 site in 1 country22 target enrollmentDecember 2012
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ConditionsCoronary Heart Disease

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Coronary Heart Disease
Sponsor
University of Edinburgh
Enrollment
22
Locations
1
Primary Endpoint
Myocardial blood flow
Status
Completed
Last Updated
7 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSitesSimilar Trials

Overview

Brief Summary

Coronary heart disease is a very common condition caused by narrowings in the blood vessel supplying the heart. the investigators are studying new tests to diagnose heart disease. In this study the investigators plan to investigate a special scan called a PET/CT (Positron emission tomography/computed tomography) and a new type of CT (Computed tomography) scan to tell us about the flow of blood to the heart muscle.

Detailed Description

Participants will undergo PET/CT with oxygen-15 labelled water and computed tomography myocardial perfusion imaging.

Registry
clinicaltrials.gov
Start Date
December 2012
End Date
January 2019
Last Updated
7 years ago
Study Type
Observational
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • •suspected coronary artery disease

Exclusion Criteria

  • •inability or unwillingness to undergo CT or PET imaging
  • •renal failure (serum creatinine \>200 um/L or eGFR \<30 ml/min)
  • •hepatic failure
  • •allergy to iodinated contrast
  • •pregnancy
  • •contraindication to adenosine
  • •inability to give informed consent
  • •atrial fibrillation with a fast ventricular rate (\>70 beats per minute)

Outcomes

Primary Outcomes

Myocardial blood flow

Time Frame: 1 month

Myocardial blood flow ( ml/g/min) measured by oxygen-15 water positron emission tomography

Secondary Outcomes

  • Myocardial perfusion(1 month)
  • Fractional flow reserve(1 month)

Study Sites (1)

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