Risk Factor Analysis for Coronary Atherosclerosis Measured by MDCT

Completed

• Conditions: Metabolic Syndrome; Atherosclerosis

• Registration Number: NCT01589224
• Lead Sponsor: Korea University

Brief Summary

Coronary MDCT (multi-detector computed tomography) has been useful screening imaging modality for the coronary artery disease. Recently, novel adipokines and hepatokines as well as various inflammatory markers have been known as direct regulators of atherosclerosis. Therefore, the investigators examine the correlation of various metabolic risk factors including adipokines and hepatokines with coronary atherosclerosis measured by coronary MDCT in apparently healthy people.

Detailed Description

Not available

Study Timeline

• Status Verified: 2012-04
• Study First Submitted: 2012-04-24
• Study First Submitted QC: 2012-04-28
• Study Start: 2012-05
• Study First Posted: 2012-05-01
• Primary Completion: 2012-08
• Last Update Submitted: 2015-10-12
• Last Update Posted: 2015-10-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

• Apparently healthy people who underwent medical routine check up in Korea Health Promotion Center.
• age > 20 years

Exclusion Criteria

• History of cardiovascular disease (myocardial infarction, unstable angina, stroke, or cardiovascular revascularization)
• Diabetes
• Stage 2 hypertension
• Severe renal or hepatic disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
relation of adipokines and hepatokines with coronary atherosclerosis measured by MDCT	3month	to examine the correlation of serum concentration of various adipokine such as adiponectin, resistin, A-FABP with coronary atheroslcerosis measured by MDCT as AGATSTON score, modified Gensini score

Secondary Outcome Measures

Name	Time	Method
relation of adipokines and hepatokines with coronary atherosclerosis measured by MDCT	3months	to examine the correlation of serum concentration of various hepatokines such as FGF-21, fetuin- A and selenoprotein P with coronary atheroslcerosis measured by MDCT as AGATSTON score, modified Gensini score
the correlation of various inflammatory markers with coronary atherosclerosis	3months

Trial Locations

Locations (1)

korea University Guro Hospital; 🇰🇷 Seoul, Korea, Republic of