NCT04766047Unknown不适用
The Effect of Dexmedetomidine on the Incidence of Acute Kidney Injury in EVAR
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Incidence of Acute Kidney Injury
研究概览
简要总结
This study will investigate the effect of dexmedetomidine on the incidence of postoperative acute kidney injury in patients undergoing EVAR under general anesthesia
详细描述
This study will compare the incidence of AKI after elective EVAR conducted under general anesthesia with and without administration of dexmedetomidine. The AKI will be evaluated through measuring NGAL and c-cystatin.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •elective EVAR under general anesthesia
- •adult patients 18- 85 years old
- •American society of anesthesiologists (ASA) physical status I - IV
排除标准
- •refusal to participate or sign the informed consent form
- •GFR < 50ml/mim
- •Bradyarrhythmia <50/min
- •Hemodynamic instability
- •Known allergy to Dexmedetomidine
- •Severe hepatic insufficiency
研究组 & 干预措施
DEXMEDETOMIDINE AND AKI
Active Comparator
The patients of the group undergoing EVAR under general anesthesia will receive dexmedetomidine intraoperatively.
干预措施: Dexmedetomidine (Drug)
结局指标
主要结局
Incidence of Acute Kidney Injury
时间窗: 1st Postoperative Day
Assess the incidence of Acute Kidney Injury after the administration of dexmedetomine
次要结局
- Incidence of Postoperative Delirium(Operation day to 4th postoperative day)
- Incidence of arrhythmia(Up to 24 hours after surgery)
- Incidence of postoperative ICU admission(Operation day to 5th postoperative day)
研究者
Elena Arnaoutoglou
Professor of anesthesiology
University of Thessaly
研究点 (1)
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