The Effect of Dexmedetomidine on Kidney Function in EVAR

Not Applicable

• Conditions: Acute Kidney Injury; Dexmedetomidine; Endovascular Aortic Repair
• Interventions: Drug: Dexmedetomidine

• Registration Number: NCT04766047
• Lead Sponsor: University of Thessaly

Brief Summary

This study will investigate the effect of dexmedetomidine on the incidence of postoperative acute kidney injury in patients undergoing EVAR under general anesthesia

Detailed Description

This study will compare the incidence of AKI after elective EVAR conducted under general anesthesia with and without administration of dexmedetomidine. The AKI will be evaluated through measuring NGAL and c-cystatin.

Study Timeline

• Study First Submitted: 2021-02-02
• Study First Submitted QC: 2021-02-20
• Study First Posted: 2021-02-23
• Status Verified: 2021-04
• Last Update Submitted: 2021-04-27
• Last Update Posted: 2021-04-28
• Study Start: 2021-08-30
• Primary Completion: 2023-11-30
• Study Completion: 2024-02-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• elective EVAR under general anesthesia
• adult patients 18- 85 years old
• American society of anesthesiologists (ASA) physical status I - IV

Exclusion Criteria

• refusal to participate or sign the informed consent form
• GFR < 50ml/mim
• Bradyarrhythmia <50/min
• Hemodynamic instability
• Known allergy to Dexmedetomidine
• Severe hepatic insufficiency

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
DEXMEDETOMIDINE AND AKI	Dexmedetomidine	The patients of the group undergoing EVAR under general anesthesia will receive dexmedetomidine intraoperatively.

Primary Outcome Measures

Name	Time	Method
Incidence of Acute Kidney Injury	1st Postoperative Day	Assess the incidence of Acute Kidney Injury after the administration of dexmedetomine

Secondary Outcome Measures

Name	Time	Method
Incidence of arrhythmia	Up to 24 hours after surgery	Record the incidence of arrhythmia postoperatively
Incidence of Postoperative Delirium	Operation day to 4th postoperative day	Record the incidence of Postoperative Delirium postoperatively
Incidence of postoperative ICU admission	Operation day to 5th postoperative day	Record the incidence of unanticipated postoperative ICU admission

Trial Locations

Locations (1)

Univeristy of Thessaly; 🇬🇷 Larissa, Thessaly, Greece