Efficacy of Cognitive Bias Modification in Residential Treatment for Addiction

Not Applicable

Completed

• Conditions: Substance Dependence
• Interventions: Behavioral: Cognitive Bias Modification

• Registration Number: NCT03000699
• Lead Sponsor: Centre for Addiction and Mental Health

Brief Summary

The purpose of this study is to determine whether computer bias modification for interpretation bias (CBM-I) is effective in the reduction of suicidal ideation in substance use disorders.

Detailed Description

Eighty-eight adult inpatients completing residential treatment in the Addictions Services at the Centre for Addiction and Mental Health (CAMH) will be randomized to receive CBM-I daily for one week, adjunct to the residential psychosocial treatment or to an assessment-only control condition. Participants will complete clinical measures consisting of interviews and questionnaires measuring suicidal ideation, hopelessness, depression, negative affect, and interpretation biases before, during and after treatment.

Study Timeline

• Study First Submitted: 2016-12-20
• Study First Submitted QC: 2016-12-20
• Study First Posted: 2016-12-22
• Study Start: 2017-03-01
• Primary Completion: 2018-10-01
• Study Completion: 2018-12-31
• Status Verified: 2019-01
• Last Update Submitted: 2019-01-29
• Last Update Posted: 2019-01-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 88

Inclusion Criteria

• Exhibit moderate suicide risk or greater
• Be enrolled in the Addictions Services inpatient program
• Fluent in reading English
• Capacity to give informed consent

Exclusion Criteria

• A lifetime diagnosis of a psychotic or bipolar disorder
• Significant neurological disorder or psychical illness likely to interfere with participation
• Psychotropic medication changes within the past two weeks

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Cognitive Bias Modification	Cognitive Bias Modification	64 training paragraphs, approximately 10-20 seconds each, digitally recorded and presented stereophonically through headphones, delivered over the course of one week.

Primary Outcome Measures

Name	Time	Method
Columbia-Suicide Severity Rating Scale, Screen Version (C-SSRS)	Seven days	This scale quantifies the severity of suicidal ideation and behaviour.

Secondary Outcome Measures

Name	Time	Method
Positive and Negative Affect Schedule (PANAS)	Seven days	This questionnaire assesses current positive and negative mood
Beck Hopelessness Scale (BHS)	Seven days	This questionnaire assesses thoughts and emotions associated with the future.
Beck Depression Inventory II (BDI-II)	Seven days	This questionnaire assesses severity of depressive symptoms and cognitions.
Scrambled Sentences Tests	Seven days	This computer test will be used as an implicit measure of negative interpretation bias.

Trial Locations

Locations (1)

Centre for Addiction and Mental Health; 🇨🇦 Toronto, Ontario, Canada