Remote Ischemic Preconditioning in Liver Transplantation

Not Applicable

• Conditions: Liver Transplanatation
• Interventions: Procedure: Ischemia preconditioining

• Registration Number: NCT02534025
• Lead Sponsor: Mansoura University

Brief Summary

Remote (upper arm) ischemic preconditioning in the donor of living donor liver transplanta to ameliorate the effect of reperfusion injury in recipients.

Detailed Description

Upper arm ischemia will be induced by elevation of NIBP cuff pressure to 200 mm Hg for 5 minutes repeated four times 5 mniutes apart, aiming to decrease the effect of ischemia reperfusion in the graft liver.

Study Timeline

• Study First Submitted: 2015-08-09
• Study First Submitted QC: 2015-08-26
• Study First Posted: 2015-08-27
• Study Start: 2016-01
• Status Verified: 2017-02
• Primary Completion: 2017-02
• Last Update Submitted: 2017-02-05
• Last Update Posted: 2017-02-07
• Study Completion: 2017-03

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• All candidates for living donor liver transplantation

Exclusion Criteria

• Donors with peripheral vascular disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
P group	Ischemia preconditioining	Elevation of Cuff pressure to 200 mm Hg for 5 minutes four times 5 minutes apart

Primary Outcome Measures

Name	Time	Method
liver enzymes ( SGOT and SGPT) as indicator of graft injury	30 minutes	Hemodynamic effects of reperfusion ijury

Trial Locations

Locations (1)

Mansoura university; 🇪🇬 Mansoura, Dkahleya, Egypt