Risk Prediction for Alzheimer Dementia With Brain Imaging and Genetics
Not Applicable
Withdrawn
- Conditions
- Alzheimer DementiaPosttraumatic Stress DisorderTraumatic Brain Injury
- Registration Number
- NCT03641768
- Lead Sponsor
- Duke University
- Brief Summary
The purpose of this study is to learn about how trauma, posttraumatic stress disorder (PTSD), and mild traumatic brain injury that can occur during deployment affect the brain. The investigators also want to learn how PTSD and mild traumatic brain injury can affect the chance of developing Alzheimer disease later in life. The investigators will study this by using magnetic resonance imaging and positron emission tomography scans to obtain pictures of the brain.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
- Age 18 to 65
- Previously enrolled in studies of OEF/OIF veterans by the same investigators
- Free of implanted metal objects or mental shards in eyes
- Fluent in English and capable of consenting
Exclusion Criteria
- Axis I disorders other than Major Depressive Disorder or PTSD
- Current substance abuse or lifetime substance dependence (other than nicotine)
- High risk for suicide
- Claustrophobia
- Neurological disorders
- Learning disability or developmental delay
- Major medical conditions
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Cortical thickness as measured by MRI scans Baseline Beta amyloid plaques as measured by PET scans Baseline Tau proteins as measured by PET scans Baseline
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Durham VA
🇺🇸Durham, North Carolina, United States
Durham VA🇺🇸Durham, North Carolina, United States