Risk Prediction for Alzheimer Dementia With Brain Imaging and Genetics
Trial Snapshot
- Phase
- Not Applicable
- Status
- Withdrawn
- Sponsor
- Duke University
- Locations
- 2
- Primary Endpoint
- Cortical thickness as measured by MRI scans
Study Overview
Brief Summary
The purpose of this study is to learn about how trauma, posttraumatic stress disorder (PTSD), and mild traumatic brain injury that can occur during deployment affect the brain. The investigators also want to learn how PTSD and mild traumatic brain injury can affect the chance of developing Alzheimer disease later in life. The investigators will study this by using magnetic resonance imaging and positron emission tomography scans to obtain pictures of the brain.
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Single Group
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Age 18 to 65
- •Previously enrolled in studies of OEF/OIF veterans by the same investigators
- •Free of implanted metal objects or mental shards in eyes
- •Fluent in English and capable of consenting
Exclusion Criteria
- •Axis I disorders other than Major Depressive Disorder or PTSD
- •Current substance abuse or lifetime substance dependence (other than nicotine)
- •High risk for suicide
- •Claustrophobia
- •Neurological disorders
- •Learning disability or developmental delay
- •Major medical conditions
Arms & Interventions
Healthy volunteers
Volunteers with no trauma history
Intervention: MRI (Device)
Healthy volunteers
Volunteers with no trauma history
Intervention: PET (Device)
Healthy volunteers
Volunteers with no trauma history
Intervention: 18F-Florbetapir (Device)
Healthy volunteers
Volunteers with no trauma history
Intervention: Radioligand 18F-AV-1451 (Device)
Trauma only
Volunteers that do not have PTSD but have had similar trauma to those with PTSD
Intervention: MRI (Device)
Trauma only
Volunteers that do not have PTSD but have had similar trauma to those with PTSD
Intervention: PET (Device)
Trauma only
Volunteers that do not have PTSD but have had similar trauma to those with PTSD
Intervention: 18F-Florbetapir (Device)
Trauma only
Volunteers that do not have PTSD but have had similar trauma to those with PTSD
Intervention: Radioligand 18F-AV-1451 (Device)
PTSD only
Volunteers with PTSD but no traumatic brain injury
Intervention: MRI (Device)
PTSD only
Volunteers with PTSD but no traumatic brain injury
Intervention: PET (Device)
PTSD only
Volunteers with PTSD but no traumatic brain injury
Intervention: 18F-Florbetapir (Device)
PTSD only
Volunteers with PTSD but no traumatic brain injury
Intervention: Radioligand 18F-AV-1451 (Device)
PTSD and TBI
Volunteers with PTSD and mild traumatic brain injury
Intervention: MRI (Device)
PTSD and TBI
Volunteers with PTSD and mild traumatic brain injury
Intervention: PET (Device)
PTSD and TBI
Volunteers with PTSD and mild traumatic brain injury
Intervention: 18F-Florbetapir (Device)
PTSD and TBI
Volunteers with PTSD and mild traumatic brain injury
Intervention: Radioligand 18F-AV-1451 (Device)
Outcomes
Primary Outcomes
Cortical thickness as measured by MRI scans
Time Frame: Baseline
Beta amyloid plaques as measured by PET scans
Time Frame: Baseline
Tau proteins as measured by PET scans
Time Frame: Baseline
Secondary Outcomes
No secondary outcomes reported