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Risk Prediction for Alzheimer Dementia With Brain Imaging and Genetics

Not Applicable
Withdrawn
Conditions
Alzheimer Dementia
Posttraumatic Stress Disorder
Traumatic Brain Injury
Interventions
Device: MRI
Device: PET
Device: 18F-Florbetapir
Device: Radioligand 18F-AV-1451
Registration Number
NCT03641768
Lead Sponsor
Duke University
Brief Summary

The purpose of this study is to learn about how trauma, posttraumatic stress disorder (PTSD), and mild traumatic brain injury that can occur during deployment affect the brain. The investigators also want to learn how PTSD and mild traumatic brain injury can affect the chance of developing Alzheimer disease later in life. The investigators will study this by using magnetic resonance imaging and positron emission tomography scans to obtain pictures of the brain.

Detailed Description

Not available

Recruitment & Eligibility

Status
WITHDRAWN
Sex
All
Target Recruitment
Not specified
Inclusion Criteria
  • Age 18 to 65
  • Previously enrolled in studies of OEF/OIF veterans by the same investigators
  • Free of implanted metal objects or mental shards in eyes
  • Fluent in English and capable of consenting
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Exclusion Criteria
  • Axis I disorders other than Major Depressive Disorder or PTSD
  • Current substance abuse or lifetime substance dependence (other than nicotine)
  • High risk for suicide
  • Claustrophobia
  • Neurological disorders
  • Learning disability or developmental delay
  • Major medical conditions
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Study & Design

Study Type
INTERVENTIONAL
Study Design
SINGLE_GROUP
Arm && Interventions
GroupInterventionDescription
Healthy volunteersMRIVolunteers with no trauma history
Healthy volunteers18F-FlorbetapirVolunteers with no trauma history
Healthy volunteersRadioligand 18F-AV-1451Volunteers with no trauma history
Trauma onlyRadioligand 18F-AV-1451Volunteers that do not have PTSD but have had similar trauma to those with PTSD
PTSD only18F-FlorbetapirVolunteers with PTSD but no traumatic brain injury
PTSD onlyMRIVolunteers with PTSD but no traumatic brain injury
PTSD and TBIMRIVolunteers with PTSD and mild traumatic brain injury
PTSD and TBI18F-FlorbetapirVolunteers with PTSD and mild traumatic brain injury
PTSD onlyPETVolunteers with PTSD but no traumatic brain injury
PTSD and TBIRadioligand 18F-AV-1451Volunteers with PTSD and mild traumatic brain injury
Healthy volunteersPETVolunteers with no trauma history
Trauma onlyMRIVolunteers that do not have PTSD but have had similar trauma to those with PTSD
Trauma onlyPETVolunteers that do not have PTSD but have had similar trauma to those with PTSD
Trauma only18F-FlorbetapirVolunteers that do not have PTSD but have had similar trauma to those with PTSD
PTSD onlyRadioligand 18F-AV-1451Volunteers with PTSD but no traumatic brain injury
PTSD and TBIPETVolunteers with PTSD and mild traumatic brain injury
Primary Outcome Measures
NameTimeMethod
Cortical thickness as measured by MRI scansBaseline
Beta amyloid plaques as measured by PET scansBaseline
Tau proteins as measured by PET scansBaseline
Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (1)

Durham VA

🇺🇸

Durham, North Carolina, United States

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