Association Between P0.1 and Extubation Failure in Adult Patients with Acute Hypoxemic Respiratory Failure. a Multicenter Prospective Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 256
- 试验地点
- 1
- 主要终点
- Extubation failure
研究概览
简要总结
The goal of this observational study is to learn about the effect of the occlusion pressure during the first 100 miliseconds (P01) over the extubation failure in participants receiving mechanical ventilation for acute respiratory failure.
The main question it aims to answer is:
Are high P0.1 values (≥3 cmH2O) measured 30 minutes after starting a spontaneous breathing trial associated with extubation failure in adult patients who were intubated for acute hypoxemic respiratory failure?
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients over 17 years of age
- •Patients receiving invasive mechanical ventilation for more than 24 hours
- •Patients who have been ventilated for acute hypoxemic respiratory failure
- •Patients who overcome a PVE
- •Patients who, after overcoming the PVE, meet the conditions to be extubated immediately after, according to the team of treating professionals who conduct the weaning
- •Patients who are in their first attempt at extubation
排除标准
- •Tracheostomized patients
- •Patients with neuromuscular disease (For example: Guillain Barré,
- •Myasthenia Gravis, Amyotrophic lateral sclerosis, etc.)
- •Patients with a decision not to reintubate
结局指标
主要结局
Extubation failure
时间窗: From enrollment to the end of follow-up at day 7
Extubation failure is defined as reintubation by day 7. The decision to reintubate a patient will be made by the treating team, who will be blinded to the P0.1 values measured during spontaneus breathing trial.
次要结局
- Cut-off point of P01(From enrollment to the end of follow-up at day 7)