NL-OMON52187招募中4 期
Suboxone (buprenorphine/naloxone) versus methadone opioid rotation in patients with escalated opioid use and chronic pain: a randomized trial. - SUMO
适应症
试验速览
- 阶段
- 4 期
- 状态
- 招募中
- 入组人数
- 100
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •- Age 18 or over.
- •- Meet ICD-11 criteria for chronic pain.
- •- Using a prescribed opioid with a morphine equivalent dose of over 60 mg per
- •day for >=3 months.
- •- Have an opioid use disorder according to the DSM-5.
- •- Wish to be treated for their opioid use disorder.
- •- Willing to comply to study procedures.
- •- Be able to give informed consent.
排除标准
- •- Pregnant, lactating, or planning to become pregnant during the study period.
- •- Have already used buprenorphine or methadone in the last 4 weeks as a
- •maintenance therapy.
- •- Escalated use of another substance that prevents safe participation in the
- •- Have acute psychiatric comorbidity.
- •- Severe respiratory insufficiency or depression, such as severe chronic
- •obstructive pulmonary disease GOLD 3 or 4.
- •- Serious medical disease, such as severe liver dysfunction (Child-Pugh B or
- •C), severe renal dysfunction (eGFR (MDRD) <=29), heart failure, current brain
- •- A Q-T interval of >=450 ms on an electrocardiograph (ECG).
- •- Hypersensitivity or allergy for buprenorphine, naloxone, methadone or any
- •other substance in the preparations of these medications.
研究者
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