CTRI/2022/07/043760RecruitingPhase 4
The comparative efficacy of Buprenorphine-naloxone with moxonidine versus Buprenorphine-naloxone with clonidine for short term detoxification in opioid use disorders
Govt Medical College Rajindra Hospital Patiala0 sites0 target enrollmentStarted: TBDLast updated:
Trial Snapshot
- Phase
- Phase 4
- Status
- Recruiting
- Sponsor
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
Eligibility Criteria
Inclusion Criteria
- •1.Patient should fulfill the criteria of opioid use disorder as DSM-5.
- •2.Patient should be in withdrawal state at the time of admission (should fulfill the DSM-5 criteria of opioid withdrawal syndrome).
- •3.Should be in the age group of 18 to 50 yrs.
- •4.Patients who will give voluntary informed consent for detoxification.
Exclusion Criteria
- •1.The patients who are diagnosed with any major physical illness, organic brain disease, epilepsy, schizophrenia, other psychosis or mental retardation will be excluded.
- •2.Current alcohol abusers or those taking any other drugs along with opioids will also be excluded.
- •3.Patients whose BP < 90/60 mmHg will also be excluded for the risk of severe hypotension.
- •4.Patients with bradycardia (heart rate < 50 beats/minute), severe bradyarrhythmia, malignant arrhythmia, heart failure or severe renal impairmentare excluded.
- •5.Pregnant and breast feeding women are to be excluded.
- •6.Elderly of age > 60 yrs are excluded.
- •7.Patients on Beta blockers, Calcium channel blockers, Tricyclic antidepressants, Digitalis that interact adversely with Clonidine.
Investigators
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