Comparison of naloxone & buprenorphine on reversal of Opioid Overdose Syndrome and withdrawal in Methadone – Dependant Patients; An experimental Study
Early Phase 1
Completed
- Conditions
- Poisoning by MethadoneMethadone Overdose.
- Registration Number
- IRCT2015011020624N1
- Lead Sponsor
- Shahid Beheshti University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 90
Inclusion Criteria
all opioid-dependant patients who refer after methadone overdose will be included and randomly assigned into either case (buprenorphine with two different doses) or control (naloxone) group.
Exclusion criteria:
1-Those younger than 12 years of age and older than 100 years will be excluded.
2- Patients with multiple drug overdoses will be excluded.
3-Patients who do not respond to the buprenorphien and naloxone doses and are in life-treathening situation will be intubated and excluded from the study.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Reversal of Respiratory Depression. Timepoint: 1 min. Method of measurement: reversal of respiratory rate.
- Secondary Outcome Measures
Name Time Method Reversal of cyanosis and increased O2 Saturation. Timepoint: 2 minutes. Method of measurement: Pulse Oximetry.