Direct validation of renal123I-MIBG scintigraphy in humans
Withdrawn
- Conditions
- sympathische zenuwstelsel en intrarenale zenuwenuptake and distribution of 123I-MIBG in the kidney (how much of the radioactive tracer 123I-MIBG is taken up by the kidney nerves)
- Registration Number
- NL-OMON40382
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Withdrawn
- Sex
- Not specified
- Target Recruitment
- 12
Inclusion Criteria
- age 18 to 85 years
- able to give informed consent
- scheduled for radical nephrectomy, nephron-sparing partial nephrectomy or nephroureterectomy (only scheduled on Tuesdays to Fridays)
Exclusion Criteria
- not willing to be informed about unexpected findings during the study
- pregnancy
- donor nephrectomy
- nephrectomy scheduled on Mondays
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>to compare in vivo total kidney 123I-MIBG uptake (by counts per pixel) by<br /><br>123I-MIBG scintigraphy to direct ex vivo 123I-MIBG uptake of the flushed kidney<br /><br>as directly assessed with phosphor imaging.</p><br>
- Secondary Outcome Measures
Name Time Method <p>- to measure distribution of 123I-MIBG within the kidney<br /><br>- to compare the quantified 123I-MIBG and distribution of 123I-MIBG as assessed<br /><br>with phosphorus imaging to the histological distribution of sympathetic nerve<br /><br>endings by immunohistochemical neuron staining.<br /><br>- to compare 123I-MIBG uptake from in vivo renal 123I-MIBG scintigraphies, with<br /><br>123I-MIBG uptake from ex vivo renal 123I-MIBG scintigraphies<br /><br>- to correlate the ex vivo renal 123I-MIBG scintigraphies with the direct ex<br /><br>vivo renal 123I-MIBG uptake as quantified by the phosphorus image plate.</p><br>