The Effect of Rosuvastatin on Adenosine Metabolism

Not Applicable

Completed

• Conditions: Adenosine Metabolism
• Interventions: Drug: placebo; Drug: rosuvastatin

• Registration Number: NCT00554138
• Lead Sponsor: Radboud University Medical Center

Brief Summary

The aim of this study is to show whether rosuvastatin influences adenosine metabolism. Therefore we will determine whether rosuvasatin increases dipyridamole-induced vasodilation by increased adenosine receptor stimulation.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-11
• Study First Submitted: 2007-11-05
• Study First Submitted QC: 2007-11-05
• Study First Posted: 2007-11-06
• Primary Completion: 2008-03
• Study Completion: 2008-04
• Status Verified: 2008-09
• Last Update Submitted: 2008-09-22
• Last Update Posted: 2008-09-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

• age 18 - 50 years
• Signed informed consent

Exclusion Criteria

• hypertension
• hypercholesterolemia
• diabetes Mellitus
• alanine aminotransferase > 90 U/L
• creatinine Kinase > 440 U/L
• cardiovascular disease
• GFR < 80 ml/min

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
1	placebo	-
2	rosuvastatin	-

Primary Outcome Measures

Name	Time	Method
forearm vasodilatory response to dipyridamole	7 days

Secondary Outcome Measures

Name	Time	Method
lipid profile	7-10 days

Trial Locations

Locations (1)

Radboud University Nijmegen Medical Centre; 🇳🇱 Nijmegen, Netherlands