NCT00554138已完成不适用
Rosuvastatin Augments Dipyridamole Induced Vasodilation by Increased Adenosine Receptor Stimulation.
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- forearm vasodilatory response to dipyridamole
研究概览
简要总结
The aim of this study is to show whether rosuvastatin influences adenosine metabolism. Therefore we will determine whether rosuvasatin increases dipyridamole-induced vasodilation by increased adenosine receptor stimulation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age 18 - 50 years
- •Signed informed consent
排除标准
- •hypertension
- •hypercholesterolemia
- •diabetes Mellitus
- •alanine aminotransferase > 90 U/L
- •creatinine Kinase > 440 U/L
- •cardiovascular disease
- •GFR < 80 ml/min
研究组 & 干预措施
1
Placebo Comparator
干预措施: placebo (Drug)
2
Experimental
干预措施: rosuvastatin (Drug)
结局指标
主要结局
forearm vasodilatory response to dipyridamole
时间窗: 7 days
次要结局
- lipid profile(7-10 days)
研究者
研究点 (1)
Loading locations...
相似试验
进行中（未招募）
不适用
Rosuvastatin augments dipyridamole induced vasodilation by increased adenosine receptor stimulatioEUCTR2007-004762-40-NLDept. Pharmacology and Toxicology
已完成
4 期
Is augmentation of PORH by rosuvastatin adenosine-receptor mediated?NL-OMON32791niversitair Medisch Centrum Sint Radboud8
进行中（未招募）
不适用
Is augmentation of PORH by rosuvastatin adenosine-receptor mediated? - rosucaf2EUCTR2008-005985-30-NLDepartment of Pharmacology-Toxicology
招募中
3 期
A clinical trial to investigate the efficiency of rosuvastatin in acute cardiomyopathy induced anthracyclineCardiomyopathyIRCT2016121213090N3Vice chancellor for research of Mazandaran University of Medical Sciences80
进行中（未招募）
1 期
Adenosine 2A Receptor Antagonism and AIH in ALSALSNCT05377424University of Florida40