Feasibility of ultra high field 7.0. Tesla MR Spectroscopy for breast cancer detection and monitoring of neo-adjuvant chemotherapy efficacy
Withdrawn
- Conditions
- breast cancerbreast neoplasm10006288
- Registration Number
- NL-OMON35742
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Withdrawn
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
- 18 years or older
- Females
- Group 1: patients selected for neo-adjuvant chemotherapy
- Group 2: patients with BIRADS 4c or 5 classification on mammography, US or lower field MRI, selected for surgery
- Group 3: healthy volunteers
Exclusion Criteria
- Any prior surgery or radiotherapy to the ipsilateral breast
- Karnofsky score <= 70
- Pregnant or lactating women
- Contra-indications to MRI scanning according to the 7T screening list of the UMCU
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>1. Sensitivity of 7T MRS detection of histological proven breast cancer. The in<br /><br>vivo 7T MRS data will be compared to ex vivo measurements with HR-MAS and LC-MS.<br /><br>2. Sensitivity of 7T MRS to monitor neo-adjuvant chemotherapy effects in<br /><br>membrane metabolism </p><br>
- Secondary Outcome Measures
Name Time Method <p>-</p><br>