The Effects of Dexmedetomidine on Postoperative Cognitive Function in Open Heart Surgery

Not Applicable

Recruiting

• Conditions: Open Heart Sugery; Neuronal Damage
• Interventions: Drug: Dexmedetomidine

• Registration Number: NCT06655025
• Lead Sponsor: Sohag University

Brief Summary

To assess the impact of Dexmedetomidine on postoperative cognitive function and serum Neuron Specific Enolase levels as an indicator of neuronal injury in patients undergoing open heart surgery

Detailed Description

Not available

Study Timeline

• Status Verified: 2024-10
• Study Start: 2024-10-08
• Study First Submitted: 2024-10-22
• Study First Submitted QC: 2024-10-22
• Last Update Submitted: 2024-10-22
• Study First Posted: 2024-10-23
• Last Update Posted: 2024-10-23
• Primary Completion: 2025-10-08
• Study Completion: 2025-10-08

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 32

Inclusion Criteria

• Patients of both sexes undergoing elective open-heart surgery

Exclusion Criteria

• Patients with a history of neurological disorders, severe renal or liver dysfunction, or contraindications to Dexmedetomidine as in patients with known QT prolongation, a history of other arrhythmias, symptomatic bradycardia, hypokalemia, or hypomagnesemia, and in patients receiving other drugs known to prolong the QT interval.

Patients with cognitive impairment, mental and psychological illness and chronic alcoholics, drug addicts, abuse of psychotropic substances, illiterate education

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group B (Dexmedetomidine)	Dexmedetomidine	Dexmedetomidine infusion
Group A (control)	Dexmedetomidine	normal saline infusion

Primary Outcome Measures

Name	Time	Method
postoperative cognitive function	pre- oprerative , Mini-mental state examination (MMSE) will be performed at 1, 3 and 7 days after operation.	using the Mini-Mental State Examination (MMSE) to evaluate cognitive status

Secondary Outcome Measures

Name	Time	Method
serum Neuron Specific Enolase levels	pre-operative ,post-operative 12 hours	serum Neuron Specific Enolase levels as an indicator of neuronal injury in patients undergoing open heart surgeries.

Trial Locations

Locations (1)

Sohag University; 🇪🇬 Sohag, Egypt