The Effects of Dexmedetomidine on Postoperative Cognitive Function and Neuron-Specific Enolase Levels in Open Heart Surgery
Overview
- Phase
- Not Applicable
- Intervention
- Dexmedetomidine
- Conditions
- Not specified
- Sponsor
- Sohag University
- Enrollment
- 32
- Locations
- 1
- Primary Endpoint
- Postoperative cognitive function
- Status
- Completed
- Last Updated
- last month
Overview
Brief Summary
To assess the impact of Dexmedetomidine on postoperative cognitive function and serum Neuron Specific Enolase levels as an indicator of neuronal injury in patients undergoing open heart surgery
Detailed Description
This randomized controlled study was conducted to evaluate the effects of dexmedetomidine on postoperative cognitive function in patients undergoing elective open-heart surgery. Patients were randomly assigned into two groups: a dexmedetomidine group receiving intravenous dexmedetomidine infusion during surgery and a control group receiving normal saline infusion as placebo in addition to standard anesthesia. Postoperative cognitive function was assessed using the Mini-Mental State Examination (MMSE). Serum neuron-specific enolase (NSE) levels were measured as a biomarker of neuronal injury. Intraoperative depth of anesthesia was monitored using the bispectral index (BIS). The aim of the study was to investigate whether dexmedetomidine administration could reduce postoperative cognitive dysfunction and neuronal injury in patients undergoing cardiac surgery.
Investigators
Salaheldin Ahmed Abdelziz
specialist
Sohag University
Eligibility Criteria
Inclusion Criteria
- •Patients of both sexes undergoing elective open-heart surgery
Exclusion Criteria
- •Patients with a history of neurological disorders, severe renal or liver dysfunction, or contraindications to Dexmedetomidine as in patients with known QT prolongation, a history of other arrhythmias, symptomatic bradycardia, hypokalemia, or hypomagnesemia, and in patients receiving other drugs known to prolong the QT interval.
- •Patients with cognitive impairment, mental and psychological illness and chronic alcoholics, drug addicts, abuse of psychotropic substances, illiterate education
Arms & Interventions
Group B (Dexmedetomidine)
Patients receive intravenous dexmedetomidine infusion during open-heart surgery in addition to standard anesthesia.
Intervention: Dexmedetomidine
Group A (control)
Patients receive intravenous normal saline infusion during surgery as placebo control in addition to standard anesthesia.
Intervention: Dexmedetomidine
Outcomes
Primary Outcomes
Postoperative cognitive function
Time Frame: Preoperative baseline, and at 1 day, 3 days, and 7 days after surgery
Cognitive function will be evaluated using the Mini-Mental State Examination (MMSE).
Secondary Outcomes
- Serum neuron-specific enolase levels(Preoperative baseline and 12 hours after surgery)