Effect of Dexmedetomidine on Postoperative Cognitive Function in Patients Undergoing Shoulder Arthroscopy With Beach Chair Position Under Desflurane Anesthesia

Not Applicable

Completed

• Conditions: Rotator Cuff Tear
• Interventions: Drug: normal saline; Drug: Dexmedetomidine

• Registration Number: NCT02643017
• Lead Sponsor: Yonsei University

Brief Summary

Investigate the effects of dexmedetomidine on postoperative cognitive function in patients undergoing shoulder arthroscopy with beach chair position under desflurane anesthesia.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2015-12-11
• Study First Submitted: 2015-12-15
• Study First Submitted QC: 2015-12-28
• Study First Posted: 2015-12-30
• Primary Completion: 2018-08-16
• Study Completion: 2018-08-16
• Status Verified: 2019-01
• Last Update Submitted: 2019-01-23
• Last Update Posted: 2019-01-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

1. Patients undergoing shoulder arthroscopic surgery with beach chair position

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Exclusion Criteria

1. Patients with respiratory disease
2. Patients with cardiac disease
3. Patients with cerebrovascular disease
4. patients with uncontrolled hypertension
5. Patients with dementia
6. Patients with psychiatric disease

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
normal saline	normal saline	-
Dex	Dexmedetomidine	-

Primary Outcome Measures

Name	Time	Method
Number of patients with postoperative cognitive decline assessed by mini-mental state examination	from 1 day before surgery to postoperative 1 day	to compare cognitive decline after surgery between control and dexmedetomidine group with mini-mental state examination.
Number of patients with postoperative cognitive decline assessed by a battery of psychometric test	from 1 day before surgery to postoperative 1 day	to compare cognitive decline after surgery between control and dexmedetomidine group with a battery of psychometric test. The battery consists of copy geometric form test, two-dimensional model test, grooved pegboard test, colored block design test, puzzle test, clock drawing test.

Secondary Outcome Measures

Name	Time	Method
Number of patients with increase of S100ß protein after surgery assessed by ELISA assay with blood of patients	from 5 min after induction of anesthesia to an 1 hour after surgery	S100ß protein is the biologic marker for neuroinflammation

Trial Locations

Locations (1)

Department of Anesthesiology and Pain Medicine, Severance Hospital, Yonsei University College of Medicine; 🇰🇷 Seoul, Korea, Republic of