Effect of Dexmedetomidine on Postoperative Cognitive Function in Patients Undergoing Shoulder Arthroscopy With Beach Chair Position Under Desflurane Anesthesia
Overview
- Phase
- Not Applicable
- Intervention
- normal saline
- Conditions
- Rotator Cuff Tear
- Sponsor
- Yonsei University
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- Number of patients with postoperative cognitive decline assessed by mini-mental state examination
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
Investigate the effects of dexmedetomidine on postoperative cognitive function in patients undergoing shoulder arthroscopy with beach chair position under desflurane anesthesia.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients undergoing shoulder arthroscopic surgery with beach chair position
Exclusion Criteria
- •Patients with respiratory disease
- •Patients with cardiac disease
- •Patients with cerebrovascular disease
- •patients with uncontrolled hypertension
- •Patients with dementia
- •Patients with psychiatric disease
Arms & Interventions
normal saline
Intervention: normal saline
Dex
Intervention: Dexmedetomidine
Outcomes
Primary Outcomes
Number of patients with postoperative cognitive decline assessed by mini-mental state examination
Time Frame: from 1 day before surgery to postoperative 1 day
to compare cognitive decline after surgery between control and dexmedetomidine group with mini-mental state examination.
Number of patients with postoperative cognitive decline assessed by a battery of psychometric test
Time Frame: from 1 day before surgery to postoperative 1 day
to compare cognitive decline after surgery between control and dexmedetomidine group with a battery of psychometric test. The battery consists of copy geometric form test, two-dimensional model test, grooved pegboard test, colored block design test, puzzle test, clock drawing test.
Secondary Outcomes
- Number of patients with increase of S100ß protein after surgery assessed by ELISA assay with blood of patients(from 5 min after induction of anesthesia to an 1 hour after surgery)