“Comparison of nebulized ketamine with nebulized magnesium sulphate on the incidence of post operative sore throat.”

Not yet recruiting

• Conditions: Medical and Surgical,

• Registration Number: CTRI/2025/04/083883
• Lead Sponsor: Government of Gujurat

Brief Summary

Post operative sore throat is still a major complaint despite all the efforts made over years in patients undergoing gernal anesthesia.Various pharmacological and non pharmacological trials have been used  to decrease the incidence of post operative sore throat. It is known that NMDA receptors have role in nociception and inflammation. Antinociceptive and antiinflammatory property of ketamine and magnesium sulfate  suggest that both have potential role in reducing post operative sore throat.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2025-01-04
• Study Start: 2025-12-04

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• o ASA grade I & II .
• o Patients weight 40-70kg of either sex.
• o Patients scheduled for elective surgery for 120 minutes to 150 minutes under general anaesthesia requiring endotracheal intubation.

Exclusion Criteria

• o ASA grade III, IV , V o Patient refusing to give consent.
• o Pre-existing upper respiratory tract infection and anticipated difficult airway.
• o Surgery involving oral cavity, nasopharynx, larynx and neck region and requiring prone position.
• o Immunocompromised patients.
• o Patients with a history of allergy to the drugs to be used.
• o Patient requiring oral nasogastric tube insertion.
• o Patients undergoing laparoscopic surgery.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To compare the incidence of POST(Post operative sore throat)	To compare the incidence of POST(Post operative sore throat) 24 hours post operative

Secondary Outcome Measures

Name	Time	Method
To compare the hemodynamic changes and other side effects .	24 hrs post operative

Trial Locations

Locations (1)

B.J.Medical College and Civil Hospital , Ahmedabad; 🇮🇳 Ahmadabad, GUJARAT, India

B.J.Medical College and Civil Hospital , Ahmedabad

🇮🇳Ahmadabad, GUJARAT, India

Dr Divya Gosai

Principal investigator

9664956732

gosaid51@gmail.com