Effect of NMN Supplementation on Organ System Biology
Not Applicable
Completed
- Conditions
- Glucose Metabolism Disorders
- Registration Number
- NCT04571008
- Lead Sponsor
- Washington University School of Medicine
- Brief Summary
The goal of this proposal is to determine whether the beneficial effects of NMN on metabolic function observed in rodents applies to people.
- Detailed Description
This study is looking at the effect of the dietary supplement "Nicotinamide mononucleotide" (NMN) on key cardiovascular and metabolic functions, specifically those that are important risk factors for diabetes and cardiovascular disease.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 56
Inclusion Criteria
- BMI 25.0-50.0 kg/m²
- Prediabetes defined as fasting plasma glucose of ≥100 mg/dL, or HbA1C ≥5.7, or HOMA-IR ≥2.5.
Exclusion Criteria
- Women who are still having menses
- Persons who take niacin, nicotinamide, or other vitamin B3-related supplementation and are not willing to discontinue supplementation for 3 weeks before medical screening and during the entire study period
- Persons who consume moderate-large amounts of caffeine daily (>2 cups of coffee or 8 oz caffeinated drinks per day) or consume less amounts of caffeine but believe withdrawal symptoms (e.g. headache) are likely if caffeine is stopped
- Unstable weight (>3% change during the last 2 months before entering the study)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Change in Muscle insulin sensitivity before and after at least 16 weeks of treatment The outcome will be assessed during hyperinsulinemic-euglycemic clamp procedure in conjunction with stable isotopic tracer infusion before and after intervention period.
- Secondary Outcome Measures
Name Time Method Changes in glucose tolerance before and after at least 16 weeks of treatment The outcome will be assessed during modified oral glucose tolerance test
Trial Locations
- Locations (1)
Washington University School of Medicine
🇺🇸Saint Louis, Missouri, United States
Washington University School of Medicine🇺🇸Saint Louis, Missouri, United States