Effects of Nicotinamide Riboside on Metabolism and Vascular Function
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Iowa State University
- Enrollment
- 16
- Locations
- 2
- Primary Endpoint
- NAD+
Study Overview
Brief Summary
The purpose of this study is to determine the effects of Nicotinamide Riboside (NR) supplementation on metabolism and vascular function following high-fat meal. Differences between young (18-35) and older (60-75) adults will be determined.
Detailed Description
The purpose of this study is to determine the effects of 7 days of Nicotinamide Riboside (NR) or placebo supplementation on metabolism and vascular function following high-fat meal. Differences between young (18-35) and older (60-75) adults will be determined.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Basic Science
- Masking
- Double (Participant, Outcomes Assessor)
Masking Description
I single investigator will be responsible for blinding. All researchers involved in collection and evaluation of data will remain blinded to treatments.
Eligibility Criteria
- Ages
- 18 Years to 75 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Age 18 to 35 (young) and 60 to 75 (older)
- •Normo- or pre-hypertensive (blood pressure <140/90 mmHg)
- •Non-smokers
- •Able to give informed consent and participate in all laboratory visits
Exclusion Criteria
- •Currently taking any medications that could interfere with cardiovascular or metabolic outcomes will be excluded from the study (e.g., beta-blockers)
- •Known metabolic (e.g. Type I or Type II diabetes, cardiovascular disease, etc.) or immunologic (e.g. HIV, cancer, autoimmune, etc.) diseases
- •Food allergies to egg, milk, soy or wheat
- •Women who are pregnant or planning to become pregnant during the course of the study,
- •Pacemaker or other implanted device
- •Unwilling to participate in the experimental protocol or blood draws will be excluded
Outcomes
Primary Outcomes
NAD+
Time Frame: 7 days
Blood and peripheral blood mononuclear cell (PBMC) levels
Secondary Outcomes
- Lipdemia(7 days)
- Vasodilatory responsiveness(7 days)
- Oxidative stress and inflammation(7 days)
Investigators
Rudy Valentine
Assistant Professor
Iowa State University