The Role of Regulatory B Cells in the Chronic Immune Thrombocytopenia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 36
- 试验地点
- 1
- 主要终点
- Regulatory B cells functionality
研究概览
简要总结
The chronic immune thrombopenia is an autoimmune disease caused by B cells. These cells produce anti platelets and megakaryocytes antibodies. Some B cells, named regulatory B cells, are known to control other cells. Their action in chronic immune thrombopenia is actually unknown.
详细描述
The chronic immune thrombopenia is an autoimmune disease caused by B cells. These cells produce anti platelets and megakaryocytes antibodies. Some B cells, named regulatory B cells, are known to control other cells. Their action in chronic immune thrombopenia is actually unknown. In our cohort of chronic immune thrombopenia and controls, we realized a flow cytometry analyze of B and T cells and a co-culture to determine regulatory B cells functionality.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Purpura, Thrombocytopenic, Idiopathic, chronic phase (>12 months)
- •no treatment or thrombopoietin receptor agonists
排除标准
- •< 18 years
- •Purpura, Thrombocytopenic, Idiopathic, acute phase
- •pregnancy
- •others causes of thrombopenia
结局指标
主要结局
Regulatory B cells functionality
时间窗: 1 week
inhibition of T cells proliferation with co-culture B and T cells
次要结局
- Cytometry immunophenotyping of B and T cells(1 week)