Effects of combined arm and leg high-intensity interval training on motor and non-motor symptoms in people with mild to moderate Parkinson's disease: A randomised controlled feasibility trial

Not Applicable

• Conditions: Parkinsons Disease; Neurological - Parkinson's disease

• Registration Number: ACTRN12623001279617
• Lead Sponsor: niversity of Sydney

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-12-08
• Last Update Posted: 8 January 2024

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Diagnosis of idiopathic PD with a severity of 3 or less on the Modified Hoehn and Yahr scale.

Exclusion Criteria

Exclusionary criteria: A rating greater than 3 on the Modified Hoehn and Yahr scale or no physician diagnosis of PD. Non-community dwelling residential status. Currently participating in greater than 150 minutes of moderate- to high-intensity exercise training (defined as aerobic, resistance or high-intensity interval training) per week. Individuals with secondary PD or other progressive neurological disease. Unstable medical conditions that would preclude individuals from exercising. Known diagnosis of current or past coronary or cerebral artery disease, symptomatic peripheral vascular or other medical conditions precluding exercise: e.g., congestive heart failure, untreated aneurysms, cardiac arrythmias including atrial fibrillation, moderate-to-severe pulmonary disease, advanced renal disease or permanent non-ambulatory status, retinopathy or history of retinal detachment, a diagnosis of dementia or significant cognitive impairment as defined by a score less than 19 on the Montreal Cognitive Assessment (MoCA) indicating difficulties in aspects such as memory, communication, and ability to focus, medications that could indicate treatment of dementia, medications that could affect neurological function and safety including but not limited to anti-psychotics, sedatives-hypnotics or narcotic analgesics, as determined by the study physician assessment. Current musculoskeletal injuries, conditions, or limitations (e.g., muscle strain/pain and joint instability) of the lower body (i.e., ankle, knee, or hip joints), or current lower back pain. Symptoms consistent with current major depressive episode, suicidality, psychosis, or active substance use disorders, as defined by the Diagnostic and Statistical Manual, version 5R (DSM-5R). Recurrent falls. Non-ambulatory status (use of walker or stick allowed). Recurrent falls. Terminal or rapidly progressive illness.

Study & Design

• Study Type: Interventional
• Study Design: Not specified