Frailty: Prevalence and Response to Left Ventricular Assist Device Therapy in Older Heart Failure Patients
Completed
- Conditions
- Systolic Heart Failure
- Registration Number
- NCT02156583
- Lead Sponsor
- Thomas Jefferson University
- Brief Summary
This is an observational study evaluating changes in frailty and associated impairments in older heart failure patients receiving left ventricular assist device therapy.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
- 60 years old or older
- Scheduled to undergo left ventricular assist device implantation at Thomas Jefferson University
Exclusion Criteria
- Unable or unwilling to provide informed consent
- Unable to complete baseline frailty assessment
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Change in frailty following left ventricular assist device implantation Baseline (prior to surgery); 10 days, 1 month, 3 months, and 6 months post-operatively Frailty will be assess based on the domains initially described by Fried and colleagues: weakness, low physical activity, unintentional weight loss, slowness and exhaustion. Additional frailty measures include the Short Physical Performance Battery (SPPB), as well as gait speed and hand grip strength as single item measures.
- Secondary Outcome Measures
Name Time Method Skeletal muscle size as measured by ultrasonography Baseline (prior to surgery); 10 days and 3 months postoperatively
Trial Locations
- Locations (1)
Thomas Jefferson University
🇺🇸Philadelphia, Pennsylvania, United States